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PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
Duchatel RJ, Jackson ER, Parackal SG, Kiltschewskij D, Findlay IJ, Mannan A, Staudt DE, Thomas BC, Germon ZP, Laternser S, Kearney PS, Jamaluddin MFB, Douglas AM, Beitaki T, McEwen HP, Persson ML, Hocke EA, Jain V, Aksu M, Manning EE, Murray HC, Verrills NM, Sun CX, Daniel P, Vilain RE, Skerrett-Byrne DA, Nixon B, Hua S, de Bock CE, Colino-Sanguino Y, Valdes-Mora F, Tsoli M, Ziegler DS, Cairns MJ, Raabe EH, Vitanza NA, Hulleman E, Phoenix TN, Koschmann C, Alvaro F, Dayas CV, Tinkle CL, Wheeler H, Whittle JR, Eisenstat DD, Firestein R, Mueller S, Valvi S, Hansford JR, Ashley DM, Gregory SG, Kilburn LB, Nazarian J, Cain JE, Dun MD. Duchatel RJ, et al. Among authors: whittle jr. J Clin Invest. 2024 Feb 6;134(6):e170329. doi: 10.1172/JCI170329. J Clin Invest. 2024. PMID: 38319732 Free PMC article.
BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience.
Trinder SM, McKay C, Power P, Topp M, Chan B, Valvi S, McCowage G, Govender D, Kirby M, Ziegler DS, Manoharan N, Hassall T, Kellie S, Heath J, Alvaro F, Wood P, Laughton S, Tsui K, Dodgshun A, Eisenstat DD, Endersby R, Luen SJ, Koh ES, Sim HW, Kong B, Gottardo NG, Whittle JR, Khuong-Quang DA, Hansford JR. Trinder SM, et al. Among authors: whittle jr. Front Oncol. 2023 Apr 14;13:1154246. doi: 10.3389/fonc.2023.1154246. eCollection 2023. Front Oncol. 2023. PMID: 37124503 Free PMC article. Review.
Plasma ctDNA enables early detection of temozolomide resistance mutations in glioma.
Jones JJ, Jones KL, Wong SQ, Whittle J, Goode D, Nguyen H, Iaria J, Stylli S, Towner J, Pieters T, Gaillard F, Kaye AH, Drummond KJ, Morokoff AP. Jones JJ, et al. Neurooncol Adv. 2024 Mar 19;6(1):vdae041. doi: 10.1093/noajnl/vdae041. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 38596716 Free PMC article.
Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor-Positive Breast Cancer.
Whittle JR, Vaillant F, Surgenor E, Policheni AN, Giner G, Capaldo BD, Chen HR, Liu HK, Dekkers JF, Sachs N, Clevers H, Fellowes A, Green T, Xu H, Fox SB, Herold MJ, Smyth GK, Gray DHD, Visvader JE, Lindeman GJ. Whittle JR, et al. Clin Cancer Res. 2020 Aug 1;26(15):4120-4134. doi: 10.1158/1078-0432.CCR-19-1872. Epub 2020 Apr 3. Clin Cancer Res. 2020. PMID: 32245900
Perioperative clinical trials for glioma: Raising the bar.
Mweempwa A, Rosenthal MA, Dimou J, Drummond KJ, Whittle JR. Mweempwa A, et al. Among authors: whittle jr. J Clin Neurosci. 2021 Jul;89:144-150. doi: 10.1016/j.jocn.2021.04.026. Epub 2021 May 11. J Clin Neurosci. 2021. PMID: 34119258 Review.
Plasma ctDNA liquid biopsy of IDH1, TERTp, and EGFRvIII mutations in glioma.
Jones JJ, Nguyen H, Wong SQ, Whittle J, Iaria J, Stylli S, Towner J, Pieters T, Gaillard F, Kaye AH, Drummond KJ, Morokoff AP. Jones JJ, et al. Neurooncol Adv. 2024 Mar 4;6(1):vdae027. doi: 10.1093/noajnl/vdae027. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 38572065 Free PMC article.
Spatial architecture of high-grade glioma reveals tumor heterogeneity within distinct domains.
Moffet JJD, Fatunla OE, Freytag L, Kriel J, Jones JJ, Roberts-Thomson SJ, Pavenko A, Scoville DK, Zhang L, Liang Y, Morokoff AP, Whittle JR, Freytag S, Best SA. Moffet JJD, et al. Among authors: whittle jr. Neurooncol Adv. 2023 Nov 1;5(1):vdad142. doi: 10.1093/noajnl/vdad142. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 38077210 Free PMC article.
78 results