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Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens.
Kim SH, Steere L, Zhang YK, McGregor C, Hahne C, Zhou Y, Liu C, Cai Y, Zhou H, Chen X, Puumala E, Duncan D, Wright GD, Liu CT, Whitesell L, Cowen LE. Kim SH, et al. Among authors: whitesell l. ACS Chem Biol. 2022 Jun 17;17(6):1343-1350. doi: 10.1021/acschembio.2c00257. Epub 2022 May 18. ACS Chem Biol. 2022. PMID: 35584803 Free PMC article.
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: whitesell l. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
173 results