Whiten DR - Search Results

1

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation.

West J, Satapathy S, Whiten DR, Kelly M, Geraghty NJ, Proctor EJ, Sormanni P, Vendruscolo M, Buxbaum JN, Ranson M, Wilson MR. West J, et al. Among authors: whiten dr. Sci Adv. 2021 Dec 10;7(50):eabf7606. doi: 10.1126/sciadv.abf7606. Epub 2021 Dec 10. Sci Adv. 2021. PMID: 34890220 Free PMC article.

2

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P. Scheidt T, et al. Among authors: whiten dr. Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr. Sci Adv. 2019. PMID: 31001578 Free PMC article.

3

Clusterin protects neurons against intracellular proteotoxicity.

Gregory JM, Whiten DR, Brown RA, Barros TP, Kumita JR, Yerbury JJ, Satapathy S, McDade K, Smith C, Luheshi LM, Dobson CM, Wilson MR. Gregory JM, et al. Among authors: whiten dr. Acta Neuropathol Commun. 2017 Nov 7;5(1):81. doi: 10.1186/s40478-017-0481-1. Acta Neuropathol Commun. 2017. PMID: 29115989 Free PMC article.

4

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR. Whiten DR, et al. Cell Rep. 2018 Jun 19;23(12):3492-3500. doi: 10.1016/j.celrep.2018.05.074. Cell Rep. 2018. PMID: 29924993 Free PMC article.

5

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D. De S, et al. Among authors: whiten dr. Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3. Nat Commun. 2019. PMID: 30948723 Free PMC article.

6

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.

Zeineddine R, Whiten DR, Farrawell NE, McAlary L, Hanspal MA, Kumita JR, Wilson MR, Yerbury JJ. Zeineddine R, et al. Among authors: whiten dr. Prion. 2017 May 4;11(3):195-204. doi: 10.1080/19336896.2017.1314426. Epub 2017 May 9. Prion. 2017. PMID: 28486039 Free PMC article.

7

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

Whiten DR, San Gil R, McAlary L, Yerbury JJ, Ecroyd H, Wilson MR. Whiten DR, et al. Sci Rep. 2016 Aug 12;6:31138. doi: 10.1038/srep31138. Sci Rep. 2016. PMID: 27516358 Free PMC article.

8

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D. De S, et al. Among authors: whiten dr. Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4. Acta Neuropathol Commun. 2019. PMID: 31349874 Free PMC article.

9

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Iljina M, et al. Among authors: whiten dr. ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29. ACS Nano. 2018. PMID: 30371053 Free PMC article.

10

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

Cox D, Whiten DR, Brown JWP, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H. Cox D, et al. Among authors: whiten dr. J Biol Chem. 2018 Mar 23;293(12):4486-4497. doi: 10.1074/jbc.M117.813865. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382725 Free PMC article.

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