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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential.
Bujotzek A, Tiefenthaler G, Lariviere L, D'Andrea L, Marquez EA, Rudloff I, Cho SX, Deen NS, Richter W, Regenass-Lechner F, Poehler A, Whisstock JC, Sydow-Andersen J, Reiser X, Schuster S, Neubauer J, Hoepfl S, Richter K, Nold MF, Nold-Petry CA, Schumacher F, Ellisdon AM. Bujotzek A, et al. Among authors: whisstock jc. Cell Chem Biol. 2022 Apr 21;29(4):586-596.e4. doi: 10.1016/j.chembiol.2021.10.004. Epub 2021 Oct 25. Cell Chem Biol. 2022. PMID: 34699747 Free article.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. Nold-Petry CA, et al. Among authors: whisstock jc. Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2. Nat Immunol. 2015. PMID: 25729923
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM. Lucato CM, et al. Among authors: whisstock jc. J Biol Chem. 2015 Aug 21;290(34):20827-20840. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24. J Biol Chem. 2015. PMID: 26112412 Free PMC article.
Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S. Ellisdon AM, et al. Among authors: whisstock jc. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15360-5. doi: 10.1073/pnas.1507622112. Epub 2015 Dec 1. Proc Natl Acad Sci U S A. 2015. PMID: 26627714 Free PMC article.
Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF. Ellisdon AM, et al. Among authors: whisstock jc. Sci Immunol. 2017 Feb 10;2(8):eaaj1548. doi: 10.1126/sciimmunol.aaj1548. Sci Immunol. 2017. PMID: 28783685
Parsing the IL-37-Mediated Suppression of Inflammasome Function.
Rudloff I, Ung HK, Dowling JK, Mansell A, D'Andrea L, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF. Rudloff I, et al. Among authors: whisstock jc. Cells. 2020 Jan 10;9(1):178. doi: 10.3390/cells9010178. Cells. 2020. PMID: 31936823 Free PMC article.
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Cho SX, Rudloff I, Lao JC, Pang MA, Goldberg R, Bui CB, McLean CA, Stock M, Klassert TE, Slevogt H, Mangan NE, Cheng W, Fischer D, Gfroerer S, Sandhu MK, Ngo D, Bujotzek A, Lariviere L, Schumacher F, Tiefenthaler G, Beker F, Collins C, Kamlin COF, König K, Malhotra A, Tan K, Theda C, Veldman A, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF. Cho SX, et al. Among authors: whisstock jc. Nat Commun. 2020 Nov 13;11(1):5794. doi: 10.1038/s41467-020-19400-w. Nat Commun. 2020. PMID: 33188181 Free PMC article.
268 results