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White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.
Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. Fernando MS, et al. Among authors: wharton sb. Stroke. 2006 Jun;37(6):1391-8. doi: 10.1161/01.STR.0000221308.94473.14. Epub 2006 Apr 20. Stroke. 2006. PMID: 16627790
Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.
Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; Medical Research Council Cognitive Function and Ageing Study Neuropathology Group. Simpson JE, et al. Among authors: wharton sb. Stroke. 2009 Feb;40(2):369-75. doi: 10.1161/STROKEAHA.108.529214. Epub 2008 Dec 24. Stroke. 2009. PMID: 19109541
Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.
Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group. Simpson JE, et al. Among authors: wharton sb. Neurobiol Aging. 2011 Oct;32(10):1795-807. doi: 10.1016/j.neurobiolaging.2011.04.013. Epub 2011 Jun 25. Neurobiol Aging. 2011. PMID: 21705112
Alpha-synuclein mRNA expression in oligodendrocytes in MSA.
Asi YT, Simpson JE, Heath PR, Wharton SB, Lees AJ, Revesz T, Houlden H, Holton JL. Asi YT, et al. Among authors: wharton sb. Glia. 2014 Jun;62(6):964-70. doi: 10.1002/glia.22653. Epub 2014 Mar 3. Glia. 2014. PMID: 24590631 Free PMC article.
DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.
Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB; MRC Cognitive Function and Ageing Study. Garwood CJ, et al. Among authors: wharton sb. Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. doi: 10.1111/nan.12156. Neuropathol Appl Neurobiol. 2014. PMID: 24861546
Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.
Al-Mashhadi S, Simpson JE, Heath PR, Dickman M, Forster G, Matthews FE, Brayne C, Ince PG, Wharton SB; Medical Research Council Cognitive Function and Ageing Study. Al-Mashhadi S, et al. Among authors: wharton sb. Brain Pathol. 2015 Sep;25(5):565-74. doi: 10.1111/bpa.12216. Epub 2014 Nov 20. Brain Pathol. 2015. PMID: 25311358 Free PMC article.
178 results