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ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.
Thurman AR, Moench TR, Hoke M, Politch JA, Cabral H, Mausser E, Nador E, Morton J, Hamorsky K, Swope K, Bratcher B, Anderson DJ, Whaley KJ. Thurman AR, et al. Among authors: whaley kj. Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2. Am J Obstet Gynecol. 2023. PMID: 36870409 Free article. Clinical Trial.
Long-term Prophylaxis Against Aerosolized Marburg Virus in Nonhuman Primates With an Afucosylated Monoclonal Antibody.
Abelson D, Barajas J, Stuart L, Kim D, Marimuthu A, Hu C, Yamamoto B, Ailor E, Whaley KJ, Vu H, Agans KN, Borisevich V, Deer DJ, Dobias NS, Woolsey C, Prasad AN, Peel JE, Lawrence WS, Cross RW, Geisbert TW, Fenton KA, Zeitlin L. Abelson D, et al. Among authors: whaley kj. J Infect Dis. 2023 Nov 13;228(Suppl 7):S701-S711. doi: 10.1093/infdis/jiad278. J Infect Dis. 2023. PMID: 37474248 Free PMC article.
ZMapp reduces diffusion of Ebola viral particles in fresh human cervicovaginal mucus.
Schaefer A, Yang B, Schroeder HA, Harit D, Humphry MS, Zeitlin L, Whaley KJ, Ravel J, Fischer WA, Lai SK. Schaefer A, et al. Among authors: whaley kj. Emerg Microbes Infect. 2024 Dec;13(1):2352520. doi: 10.1080/22221751.2024.2352520. Epub 2024 May 16. Emerg Microbes Infect. 2024. PMID: 38713593 Free PMC article.
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC. Zeitlin L, et al. Among authors: whaley kj. Sci Transl Med. 2024 Apr 3;16(741):eadl2055. doi: 10.1126/scitranslmed.adl2055. Epub 2024 Apr 3. Sci Transl Med. 2024. PMID: 38569014
Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody.
Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Nador E, et al. Among authors: whaley kj. Antibodies (Basel). 2024 Mar 6;13(1):17. doi: 10.3390/antib13010017. Antibodies (Basel). 2024. PMID: 38534207 Free PMC article.
Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana.
Swope K, Morton J, Pogue GP, Burden L, Partain N, Hume S, Shepherd J, Simpson CA, Brennan MB, Furman TC, Kingrey-Gebe S, Martinez T, McDonough J, Pauly MH, Whaley KJ, Zeitlin L, Bratcher B, Haydon H. Swope K, et al. Among authors: whaley kj. MAbs. 2022 Jan-Dec;14(1):2013594. doi: 10.1080/19420862.2021.2013594. MAbs. 2022. PMID: 35000569 Free PMC article.
Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Shrestha B, Vincent K, Schaefer A, Zhu Y, Vargas G, Motamedi M, Swope K, Morton J, Simpson C, Pham H, Brennan MB, Pauly MH, Zeitlin L, Bratcher B, Whaley KJ, Moench TR, Lai SK. Shrestha B, et al. Among authors: whaley kj. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107832118. doi: 10.1073/pnas.2107832118. Proc Natl Acad Sci U S A. 2021. PMID: 34815336 Free PMC article.
85 results