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Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys.
Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Ray KP, Donnelly MC, Wahlich JC, Humphreys JI, Robinson JR, Whale GA, West MR. Crowe JS, et al. Among authors: whale ga. Drug Dev Ind Pharm. 2019 Mar;45(3):387-394. doi: 10.1080/03639045.2018.1542708. Epub 2018 Nov 25. Drug Dev Ind Pharm. 2019. PMID: 30395728