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Page 1
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Boudewijns R, Thibaut HJ, Kaptein SJF, Li R, Vergote V, Seldeslachts L, Van Weyenbergh J, De Keyzer C, Bervoets L, Sharma S, Liesenborghs L, Ma J, Jansen S, Van Looveren D, Vercruysse T, Wang X, Jochmans D, Martens E, Roose K, De Vlieger D, Schepens B, Van Buyten T, Jacobs S, Liu Y, Martí-Carreras J, Vanmechelen B, Wawina-Bokalanga T, Delang L, Rocha-Pereira J, Coelmont L, Chiu W, Leyssen P, Heylen E, Schols D, Wang L, Close L, Matthijnssens J, Van Ranst M, Compernolle V, Schramm G, Van Laere K, Saelens X, Callewaert N, Opdenakker G, Maes P, Weynand B, Cawthorne C, Vande Velde G, Wang Z, Neyts J, Dallmeier K. Boudewijns R, et al. Among authors: weynand b. Nat Commun. 2020 Nov 17;11(1):5838. doi: 10.1038/s41467-020-19684-y. Nat Commun. 2020. PMID: 33203860 Free PMC article.
Another case of "European hantavirus pulmonary syndrome" with severe lung, prior to kidney, involvement, and diagnosed by viral inclusions in lung macrophages.
Gizzi M, Delaere B, Weynand B, Clement J, Maes P, Vergote V, Laenen L, Hjelle B, Verroken A, Dive A, Michaux I, Evrard P, Creytens D, Bulpa P. Gizzi M, et al. Among authors: weynand b. Eur J Clin Microbiol Infect Dis. 2013 Oct;32(10):1341-5. doi: 10.1007/s10096-013-1885-x. Epub 2013 May 14. Eur J Clin Microbiol Infect Dis. 2013. PMID: 23670277 Free PMC article.
Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology.
Wauters E, Thevissen K, Wouters C, Bosisio FM, De Smet F, Gunst J, Humblet-Baron S, Lambrechts D, Liston A, Matthys P, Neyts J, Proost P, Weynand B, Wauters J, Tejpar S, Garg AD. Wauters E, et al. Among authors: weynand b. Front Immunol. 2020 Jul 3;11:1642. doi: 10.3389/fimmu.2020.01642. eCollection 2020. Front Immunol. 2020. PMID: 32719686 Free PMC article. No abstract available.
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity.
Kaptein SJF, Jacobs S, Langendries L, Seldeslachts L, Ter Horst S, Liesenborghs L, Hens B, Vergote V, Heylen E, Barthelemy K, Maas E, De Keyzer C, Bervoets L, Rymenants J, Van Buyten T, Zhang X, Abdelnabi R, Pang J, Williams R, Thibaut HJ, Dallmeier K, Boudewijns R, Wouters J, Augustijns P, Verougstraete N, Cawthorne C, Breuer J, Solas C, Weynand B, Annaert P, Spriet I, Vande Velde G, Neyts J, Rocha-Pereira J, Delang L. Kaptein SJF, et al. Among authors: weynand b. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26955-26965. doi: 10.1073/pnas.2014441117. Epub 2020 Oct 9. Proc Natl Acad Sci U S A. 2020. PMID: 33037151 Free PMC article.
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Sanchez-Felipe L, Vercruysse T, Sharma S, Ma J, Lemmens V, Van Looveren D, Arkalagud Javarappa MP, Boudewijns R, Malengier-Devlies B, Liesenborghs L, Kaptein SJF, De Keyzer C, Bervoets L, Debaveye S, Rasulova M, Seldeslachts L, Li LH, Jansen S, Yakass MB, Verstrepen BE, Böszörményi KP, Kiemenyi-Kayere G, van Driel N, Quaye O, Zhang X, Ter Horst S, Mishra N, Deboutte W, Matthijnssens J, Coelmont L, Vandermeulen C, Heylen E, Vergote V, Schols D, Wang Z, Bogers W, Kuiken T, Verschoor E, Cawthorne C, Van Laere K, Opdenakker G, Vande Velde G, Weynand B, Teuwen DE, Matthys P, Neyts J, Jan Thibaut H, Dallmeier K. Sanchez-Felipe L, et al. Among authors: weynand b. Nature. 2021 Feb;590(7845):320-325. doi: 10.1038/s41586-020-3035-9. Epub 2020 Dec 1. Nature. 2021. PMID: 33260195
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.
Wauters E, Van Mol P, Garg AD, Jansen S, Van Herck Y, Vanderbeke L, Bassez A, Boeckx B, Malengier-Devlies B, Timmerman A, Van Brussel T, Van Buyten T, Schepers R, Heylen E, Dauwe D, Dooms C, Gunst J, Hermans G, Meersseman P, Testelmans D, Yserbyt J, Tejpar S, De Wever W, Matthys P; CONTAGIOUS collaborators; Neyts J, Wauters J, Qian J, Lambrechts D. Wauters E, et al. Cell Res. 2021 Mar;31(3):272-290. doi: 10.1038/s41422-020-00455-9. Epub 2021 Jan 21. Cell Res. 2021. PMID: 33473155 Free PMC article.
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial.
Liesenborghs L, Spriet I, Jochmans D, Belmans A, Gyselinck I, Teuwen LA, Ter Horst S, Dreesen E, Geukens T, Engelen MM, Landeloos E, Geldhof V, Ceunen H, Debaveye B, Vandenberk B, Van der Linden L, Jacobs S, Langendries L, Boudewijns R, Do TND, Chiu W, Wang X, Zhang X, Weynand B, Vanassche T, Devos T, Meyfroidt G, Janssens W, Vos R, Vermeersch P, Wauters J, Verbeke G, De Munter P, Kaptein SJF, Rocha-Pereira J, Delang L, Van Wijngaerden E, Neyts J, Verhamme P. Liesenborghs L, et al. Among authors: weynand b. EBioMedicine. 2021 Apr;66:103288. doi: 10.1016/j.ebiom.2021.103288. Epub 2021 Mar 19. EBioMedicine. 2021. PMID: 33752127 Free PMC article. Clinical Trial.
Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters.
Abdelnabi R, Boudewijns R, Foo CS, Seldeslachts L, Sanchez-Felipe L, Zhang X, Delang L, Maes P, Kaptein SJF, Weynand B, Vande Velde G, Neyts J, Dallmeier K. Abdelnabi R, et al. Among authors: weynand b. EBioMedicine. 2021 Jun;68:103403. doi: 10.1016/j.ebiom.2021.103403. Epub 2021 May 25. EBioMedicine. 2021. PMID: 34049240 Free PMC article.
Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens".
Liesenborghs L, Spriet I, Jochmans D, Belmans A, Gyselinck I, Teuwen LA, Ter Horst S, Dreesen E, Geukens T, Engelen MM, Landeloos E, Geldhof V, Ceunen H, Debaveye B, Vandenberk B, Van der Linden L, Jacobs S, Langendries L, Boudewijns R, Dan Do TN, Chiu W, Wang X, Zhang X, Weynand B, Vanassche T, Devos T, Meyfroidt G, Janssens W, Vos R, Vermeersch P, Wauters J, Verbeke G, De Munter P, Kaptein SJF, Rocha-Pereira J, Delang L, Van Wijngaerden E, Neyts J, Verhamme P. Liesenborghs L, et al. Among authors: weynand b. EBioMedicine. 2021 Jul;69:103454. doi: 10.1016/j.ebiom.2021.103454. Epub 2021 Jun 26. EBioMedicine. 2021. PMID: 34186486 Free PMC article. No abstract available.
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity.
Vanderbeke L, Van Mol P, Van Herck Y, De Smet F, Humblet-Baron S, Martinod K, Antoranz A, Arijs I, Boeckx B, Bosisio FM, Casaer M, Dauwe D, De Wever W, Dooms C, Dreesen E, Emmaneel A, Filtjens J, Gouwy M, Gunst J, Hermans G, Jansen S, Lagrou K, Liston A, Lorent N, Meersseman P, Mercier T, Neyts J, Odent J, Panovska D, Penttila PA, Pollet E, Proost P, Qian J, Quintelier K, Raes J, Rex S, Saeys Y, Sprooten J, Tejpar S, Testelmans D, Thevissen K, Van Buyten T, Vandenhaute J, Van Gassen S, Velásquez Pereira LC, Vos R, Weynand B, Wilmer A, Yserbyt J, Garg AD, Matthys P, Wouters C, Lambrechts D, Wauters E, Wauters J. Vanderbeke L, et al. Among authors: weynand b. Nat Commun. 2021 Jul 5;12(1):4117. doi: 10.1038/s41467-021-24360-w. Nat Commun. 2021. PMID: 34226537 Free PMC article.
223 results