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Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM. Chao H, et al. Among authors: wexler rr. J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18. J Med Chem. 2013. PMID: 23368907
Orally active isoxazoline glycoprotein IIb/IIIa antagonists with extended duration of action.
Olson RE, Sielecki TM, Wityak J, Pinto DJ, Batt DG, Frietze WE, Liu J, Tobin AE, Orwat MJ, Di Meo SV, Houghton GC, Lalka GK, Mousa SA, Racanelli AL, Hausner EA, Kapil RP, Rabel SR, Thoolen MJ, Reilly TM, Anderson PS, Wexler RR. Olson RE, et al. Among authors: wexler rr. J Med Chem. 1999 Apr 8;42(7):1178-92. doi: 10.1021/jm980348t. J Med Chem. 1999. PMID: 10197962
Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).
Pitts WJ, Wityak J, Smallheer JM, Tobin AE, Jetter JW, Buynitsky JS, Harlow PP, Solomon KA, Corjay MH, Mousa SA, Wexler RR, Jadhav PK. Pitts WJ, et al. Among authors: wexler rr. J Med Chem. 2000 Jan 13;43(1):27-40. doi: 10.1021/jm9900321. J Med Chem. 2000. PMID: 10633036
Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).
Batt DG, Petraitis JJ, Houghton GC, Modi DP, Cain GA, Corjay MH, Mousa SA, Bouchard PJ, Forsythe MS, Harlow PP, Barbera FA, Spitz SM, Wexler RR, Jadhav PK. Batt DG, et al. Among authors: wexler rr. J Med Chem. 2000 Jan 13;43(1):41-58. doi: 10.1021/jm990049j. J Med Chem. 2000. PMID: 10633037
Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
Quan ML, Ellis CD, He MY, Liauw AY, Woerner FJ, Alexander RS, Knabb RM, Lam PY, Luettgen JM, Wong PC, Wright MR, Wexler RR. Quan ML, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2003 Feb 10;13(3):369-73. doi: 10.1016/s0960-894x(02)00951-4. Bioorg Med Chem Lett. 2003. PMID: 12565931
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors.
Quan ML, Ellis CD, He MY, Liauw AY, Lam PY, Rossi KA, Knabb RM, Luettgen JM, Wright MR, Wong PC, Wexler RR. Quan ML, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1023-8. doi: 10.1016/s0960-894x(03)00080-5. Bioorg Med Chem Lett. 2003. PMID: 12643903
194 results