Wexler RR - Search Results

1

Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.

Quan ML, Lam PY, Han Q, Pinto DJ, He MY, Li R, Ellis CD, Clark CG, Teleha CA, Sun JH, Alexander RS, Bai S, Luettgen JM, Knabb RM, Wong PC, Wexler RR. Quan ML, et al. Among authors: wexler rr. J Med Chem. 2005 Mar 24;48(6):1729-44. doi: 10.1021/jm0497949. J Med Chem. 2005. PMID: 15771420

2

Rationale for the chemical development of angiotensin II receptor antagonists.

Wexler RR, Carini DJ, Duncia JV, Johnson AL, Wells GJ, Chiu AT, Wong PC, Timmermans PB. Wexler RR, et al. Am J Hypertens. 1992 Dec;5(12 Pt 2):209S-220S. doi: 10.1093/ajh/5.12.209s. Am J Hypertens. 1992. PMID: 1290616 Review.

3

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.

Duncia JV, Carini DJ, Chiu AT, Johnson AL, Price WA, Wong PC, Wexler RR, Timmermans PB. Duncia JV, et al. Among authors: wexler rr. Med Res Rev. 1992 Mar;12(2):149-91. doi: 10.1002/med.2610120203. Med Res Rev. 1992. PMID: 1619965 Review. No abstract available.

4

The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Johnson AL, Wexler RR. Timmermans PB, et al. Among authors: wexler rr. Am J Hypertens. 1991 Apr;4(4 Pt 2):275S-281S. doi: 10.1093/ajh/4.4.275s. Am J Hypertens. 1991. PMID: 1854452 Review.

5

In vivo pharmacology of DuP 753.

Wong PC, Price WA Jr, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB. Wong PC, et al. Among authors: wexler rr. Am J Hypertens. 1991 Apr;4(4 Pt 2):288S-298S. doi: 10.1093/ajh/4.4.288s. Am J Hypertens. 1991. PMID: 1854454 Review.

6

Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Timmermans PB, et al. Among authors: wexler rr. Hypertension. 1991 Nov;18(5 Suppl):III136-42. doi: 10.1161/01.hyp.18.5_suppl.iii136. Hypertension. 1991. PMID: 1937677 Review.

7

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1995 Jul 21;38(15):2938-45. doi: 10.1021/jm00015a016. J Med Chem. 1995. PMID: 7636854

8

EXP597, a nonpeptide angiotensin II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes.

Wong PC, Duncia JV, Santella JB 3rd, Smith RD, Wexler RR, Timmermans PB, Chiu AT. Wong PC, et al. Among authors: wexler rr. Eur J Pharmacol. 1994 Aug 1;260(2-3):261-4. doi: 10.1016/0014-2999(94)90348-4. Eur J Pharmacol. 1994. PMID: 7988654

9

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

VanAtten MK, Ensinger CL, Chiu AT, McCall DE, Nguyen TT, Wexler RR, Timmermans PB. VanAtten MK, et al. Among authors: wexler rr. J Med Chem. 1993 Dec 10;36(25):3985-92. doi: 10.1021/jm00077a001. J Med Chem. 1993. PMID: 8258820

10

Discovery of losartan, the first angiotensin II receptor antagonist.

Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD. Timmermans PB, et al. Among authors: wexler rr. J Hum Hypertens. 1995 Nov;9 Suppl 5:S3-18. J Hum Hypertens. 1995. PMID: 8583479 Review.

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