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Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.
Shaw J, Gosain R, Kalita MM, Foster TL, Kankanala J, Mahato DR, Abas S, King BJ, Scott C, Brown E, Bentham MJ, Wetherill L, Bloy A, Samson A, Harris M, Mankouri J, Rowlands DJ, Macdonald A, Tarr AW, Fischer WB, Foster R, Griffin S. Shaw J, et al. Elife. 2020 Nov 10;9:e52555. doi: 10.7554/eLife.52555. Elife. 2020. PMID: 33169665 Free PMC article.
Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.
Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S. Foster TL, et al. Among authors: wetherill lf. Hepatology. 2014 Feb;59(2):408-22. doi: 10.1002/hep.26685. Epub 2013 Dec 24. Hepatology. 2014. PMID: 24022996 Free PMC article.
Controlled infection with a therapeutic virus defines the activation kinetics of human natural killer cells in vivo.
El-Sherbiny YM, Holmes TD, Wetherill LF, Black EV, Wilson EB, Phillips SL, Scott GB, Adair RA, Dave R, Scott KJ, Morgan RS, Coffey M, Toogood GJ, Melcher AA, Cook GP. El-Sherbiny YM, et al. Among authors: wetherill lf. Clin Exp Immunol. 2015 Apr;180(1):98-107. doi: 10.1111/cei.12562. Clin Exp Immunol. 2015. PMID: 25469725 Free PMC article. Clinical Trial.
The tachykinin receptor 3 is associated with alcohol and cocaine dependence.
Foroud T, Wetherill LF, Kramer J, Tischfield JA, Nurnberger JI Jr, Schuckit MA, Xuei X, Edenberg HJ. Foroud T, et al. Among authors: wetherill lf. Alcohol Clin Exp Res. 2008 Jun;32(6):1023-30. doi: 10.1111/j.1530-0277.2008.00663.x. Epub 2008 Apr 15. Alcohol Clin Exp Res. 2008. PMID: 18422838 Free PMC article.
16 results