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Page 1
A tubulin binding molecule drives differentiation of acute myeloid leukemia cells.
Jackson TR, Vuorinen A, Josa-Culleré L, Madden KS, Conole D, Cogswell TJ, Wilkinson IVL, Kettyle LM, Zhang D, O'Mahony A, Gracias D, McCall L, Westwood R, Terstappen GC, Davies SG, Tate EW, Wynne GM, Vyas P, Russell AJ, Milne TA. Jackson TR, et al. Among authors: westwood r. iScience. 2022 Jul 19;25(8):104787. doi: 10.1016/j.isci.2022.104787. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992086 Free PMC article.
Stemistry: the control of stem cells in situ using chemistry.
Davies SG, Kennewell PD, Russell AJ, Seden PT, Westwood R, Wynne GM. Davies SG, et al. Among authors: westwood r. J Med Chem. 2015 Apr 9;58(7):2863-94. doi: 10.1021/jm500838d. Epub 2015 Jan 15. J Med Chem. 2015. PMID: 25590360 Review.
Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bataille CJ, Brennan MB, Byrne S, Davies SG, Durbin M, Fedorov O, Huber KV, Jones AM, Knapp S, Liu G, Nadali A, Quevedo CE, Russell AJ, Walker RG, Westwood R, Wynne GM. Bataille CJ, et al. Among authors: westwood r. Bioorg Med Chem. 2017 May 1;25(9):2657-2665. doi: 10.1016/j.bmc.2017.02.056. Epub 2017 Feb 28. Bioorg Med Chem. 2017. PMID: 28341403 Free article.
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Wilson SC, Atrash B, Barlow C, Eccles S, Fischer PM, Hayes A, Kelland L, Jackson W, Jarman M, Mirza A, Moreno J, Nutley BP, Raynaud FI, Sheldrake P, Walton M, Westwood R, Whittaker S, Workman P, McDonald E. Wilson SC, et al. Among authors: westwood r. Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. doi: 10.1016/j.bmc.2011.08.051. Epub 2011 Aug 31. Bioorg Med Chem. 2011. PMID: 21982796
Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.
Kuo EA, Hambleton PT, Kay DP, Evans PL, Matharu SS, Little E, McDowall N, Jones CB, Hedgecock CJ, Yea CM, Chan AW, Hairsine PW, Ager IR, Tully WR, Williamson RA, Westwood R. Kuo EA, et al. Among authors: westwood r. J Med Chem. 1996 Nov 8;39(23):4608-21. doi: 10.1021/jm9604437. J Med Chem. 1996. PMID: 8917650
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.
Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Moss D, Thomson TA, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: westwood r. J Biol Chem. 1995 Sep 22;270(38):22467-72. doi: 10.1074/jbc.270.38.22467. J Biol Chem. 1995. PMID: 7673235 Free article.
Dihydroorotate dehydrogenase is a target for the biological effects of leflunomide.
Williamson RA, Yea CM, Robson PA, Curnock AP, Gadher S, Hambleton AB, Woodward K, Bruneau JM, Hambleton P, Spinella-Jaegle S, Morand P, Courtin O, Sautés C, Westwood R, Hercend T, Kuo EA, Ruuth E. Williamson RA, et al. Among authors: westwood r. Transplant Proc. 1996 Dec;28(6):3088-91. Transplant Proc. 1996. PMID: 8962196 No abstract available.
39 results