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Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.
Mortimer CG, Wells G, Crochard JP, Stone EL, Bradshaw TD, Stevens MF, Westwell AD. Mortimer CG, et al. Among authors: westwell ad. J Med Chem. 2006 Jan 12;49(1):179-85. doi: 10.1021/jm050942k. J Med Chem. 2006. PMID: 16392802
Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648).
Aiello S, Wells G, Stone EL, Kadri H, Bazzi R, Bell DR, Stevens MF, Matthews CS, Bradshaw TD, Westwell AD. Aiello S, et al. Among authors: westwell ad. J Med Chem. 2008 Aug 28;51(16):5135-9. doi: 10.1021/jm800418z. Epub 2008 Jul 31. J Med Chem. 2008. PMID: 18666770
113 results