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Page 1
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.
Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, Hamdi M, van Nes J, Westerman BA, van Arkel J, Ebus ME, Haneveld F, Lakeman A, Schild L, Molenaar P, Stroeken P, van Noesel MM, Ora I, Santo EE, Caron HN, Westerhout EM, Versteeg R. Molenaar JJ, et al. Among authors: westerhout em. Nature. 2012 Feb 22;483(7391):589-93. doi: 10.1038/nature10910. Nature. 2012. PMID: 22367537 Free article.
High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.
Bate-Eya LT, den Hartog IJ, van der Ploeg I, Schild L, Koster J, Santo EE, Westerhout EM, Versteeg R, Caron HN, Molenaar JJ, Dolman ME. Bate-Eya LT, et al. Among authors: westerhout em. Oncotarget. 2016 May 10;7(19):27946-58. doi: 10.18632/oncotarget.8547. Oncotarget. 2016. PMID: 27056887 Free PMC article.
Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors.
Westerhout EM, Hamdi M, Stroeken P, Nowakowska NE, Lakeman A, van Arkel J, Hasselt NE, Bleijlevens B, Akogul N, Haneveld F, Chan A, van Sluis P, Zwijnenburg D, Volckmann R, van Noesel CJM, Adameyko I, van Groningen T, Koster J, Valentijn LJ, van Nes J, Versteeg R. Westerhout EM, et al. Cancer Res. 2022 Feb 1;82(3):484-496. doi: 10.1158/0008-5472.CAN-21-1621. Epub 2021 Dec 1. Cancer Res. 2022. PMID: 34853072
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma.
van Groningen T, Akogul N, Westerhout EM, Chan A, Hasselt NE, Zwijnenburg DA, Broekmans M, Stroeken P, Haneveld F, Hooijer GKJ, Savci-Heijink CD, Lakeman A, Volckmann R, van Sluis P, Valentijn LJ, Koster J, Versteeg R, van Nes J. van Groningen T, et al. Among authors: westerhout em. Nat Commun. 2019 Apr 4;10(1):1530. doi: 10.1038/s41467-019-09470-w. Nat Commun. 2019. PMID: 30948783 Free PMC article.
Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth.
Lamers F, Schild L, den Hartog IJ, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ. Lamers F, et al. Among authors: westerhout em. Eur J Cancer. 2012 Nov;48(16):3093-103. doi: 10.1016/j.ejca.2012.01.037. Epub 2012 Feb 25. Eur J Cancer. 2012. PMID: 22366560 Free article.
Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.
Molenaar JJ, Koster J, Ebus ME, van Sluis P, Westerhout EM, de Preter K, Gisselsson D, Øra I, Speleman F, Caron HN, Versteeg R. Molenaar JJ, et al. Among authors: westerhout em. Genes Chromosomes Cancer. 2012 Jan;51(1):10-9. doi: 10.1002/gcc.20926. Epub 2011 Oct 27. Genes Chromosomes Cancer. 2012. PMID: 22034077
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells.
Molenaar JJ, Ebus ME, Geerts D, Koster J, Lamers F, Valentijn LJ, Westerhout EM, Versteeg R, Caron HN. Molenaar JJ, et al. Among authors: westerhout em. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12968-73. doi: 10.1073/pnas.0901418106. Epub 2009 Jun 12. Proc Natl Acad Sci U S A. 2009. PMID: 19525400 Free PMC article.
26 results