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A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.
Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D. Mercer RCC, et al. Among authors: westaway d. PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan. PLoS Pathog. 2018. PMID: 29338055 Free PMC article.
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D. Watts JC, et al. Among authors: westaway d. EMBO J. 2007 Sep 5;26(17):4038-50. doi: 10.1038/sj.emboj.7601830. Epub 2007 Aug 16. EMBO J. 2007. PMID: 17703189 Free PMC article.
Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.
Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Watts JC, et al. Among authors: westaway d. PLoS Pathog. 2009 Oct;5(10):e1000608. doi: 10.1371/journal.ppat.1000608. Epub 2009 Oct 2. PLoS Pathog. 2009. PMID: 19798432 Free PMC article.
Wild-type Shadoo proteins convert to amyloid-like forms under native conditions.
Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Daude N, et al. Among authors: westaway d. J Neurochem. 2010 Apr;113(1):92-104. doi: 10.1111/j.1471-4159.2010.06575.x. Epub 2010 Jan 8. J Neurochem. 2010. PMID: 20067571 Free article.
Family reunion--the ZIP/prion gene family.
Ehsani S, Huo H, Salehzadeh A, Pocanschi CL, Watts JC, Wille H, Westaway D, Rogaeva E, St George-Hyslop PH, Schmitt-Ulms G. Ehsani S, et al. Among authors: westaway d. Prog Neurobiol. 2011 Mar;93(3):405-20. doi: 10.1016/j.pneurobio.2010.12.001. Epub 2010 Dec 14. Prog Neurobiol. 2011. PMID: 21163327 Review.
221 results