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Prion inhibition with multivalent PrPSc binding compounds.
Mays CE, Joy S, Li L, Yu L, Genovesi S, West FG, Westaway D. Mays CE, et al. Among authors: westaway d. Biomaterials. 2012 Oct;33(28):6808-22. doi: 10.1016/j.biomaterials.2012.06.004. Epub 2012 Jun 28. Biomaterials. 2012. PMID: 22748770
Wild-type Shadoo proteins convert to amyloid-like forms under native conditions.
Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Daude N, et al. Among authors: westaway d. J Neurochem. 2010 Apr;113(1):92-104. doi: 10.1111/j.1471-4159.2010.06575.x. Epub 2010 Jan 8. J Neurochem. 2010. PMID: 20067571 Free article.
Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.
Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA. Westaway D, et al. PLoS Pathog. 2011 Nov;7(11):e1002391. doi: 10.1371/journal.ppat.1002391. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114562 Free PMC article.
RGG repeats of PrP-like Shadoo protein bind nucleic acids.
Lau A, Mays CE, Genovesi S, Westaway D. Lau A, et al. Among authors: westaway d. Biochemistry. 2012 Nov 13;51(45):9029-31. doi: 10.1021/bi301395w. Epub 2012 Nov 2. Biochemistry. 2012. PMID: 23121093
Endoproteolytic processing of the mammalian prion glycoprotein family.
Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Mays CE, et al. Among authors: westaway d. FEBS J. 2014 Feb;281(3):862-76. doi: 10.1111/febs.12654. Epub 2013 Dec 23. FEBS J. 2014. PMID: 24286250 Free article.
Prion disease tempo determined by host-dependent substrate reduction.
Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG. Mays CE, et al. Among authors: westaway d. J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16. J Clin Invest. 2014. PMID: 24430187 Free PMC article.
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.
Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D. Lau A, et al. Among authors: westaway d. EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588. EMBO Mol Med. 2015. PMID: 25661904 Free PMC article.
221 results