West FG - Search Results

1

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.

Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K. Ganesan A, et al. Among authors: west fg. Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6. Sci Rep. 2019. PMID: 31455818 Free PMC article.

2

Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides.

Soueidan OM, Scully TW, Kaur J, Panigrahi R, Belovodskiy A, Do V, Matier CD, Lemieux MJ, Wuest F, Cheeseman C, West FG. Soueidan OM, et al. Among authors: west fg. ACS Chem Biol. 2017 Apr 21;12(4):1087-1094. doi: 10.1021/acschembio.6b01101. Epub 2017 Mar 2. ACS Chem Biol. 2017. PMID: 28205432

3

Evidence for heterolytic cleavage of a cyclic oxonium ylide: implications for the mechanism of the Stevens [1,2]-shift.

Hosseini SN, Johnston JR, West FG. Hosseini SN, et al. Among authors: west fg. Chem Commun (Camb). 2017 Nov 23;53(94):12654-12656. doi: 10.1039/c7cc07716e. Chem Commun (Camb). 2017. PMID: 29125612

4

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.

Li MX, Gelozia S, Danmaliki GI, Wen Y, Liu PB, Lemieux MJ, West FG, Sykes BD, Hwang PM. Li MX, et al. Among authors: west fg. Biochem Biophys Rep. 2018 Nov 1;16:145-151. doi: 10.1016/j.bbrep.2018.10.012. eCollection 2018 Dec. Biochem Biophys Rep. 2018. PMID: 30417133 Free PMC article.

5

Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.

Elmenoufy AH, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan OM, Weilbeer C, Mani RS, Barakat KH, Tuszynski JA, Weinfeld M, West FG. Elmenoufy AH, et al. Among authors: west fg. J Med Chem. 2019 Sep 12;62(17):7684-7696. doi: 10.1021/acs.jmedchem.9b00326. Epub 2019 Aug 22. J Med Chem. 2019. PMID: 31369707

6

Computer-aided drug design of small molecule inhibitors of the ERCC1-XPF protein-protein interaction.

Gentile F, Elmenoufy AH, Ciniero G, Jay D, Karimi-Busheri F, Barakat KH, Weinfeld M, West FG, Tuszynski JA. Gentile F, et al. Among authors: west fg. Chem Biol Drug Des. 2020 Apr;95(4):460-471. doi: 10.1111/cbdd.13660. Epub 2020 Jan 20. Chem Biol Drug Des. 2020. PMID: 31891209

7

Inhibition of triple negative breast cancer metastasis and invasiveness by novel drugs that target epithelial to mesenchymal transition.

Garcia E, Luna I, Persad KL, Agopsowicz K, Jay DA, West FG, Hitt MM, Persad S. Garcia E, et al. Among authors: west fg. Sci Rep. 2021 Jun 3;11(1):11757. doi: 10.1038/s41598-021-91344-7. Sci Rep. 2021. PMID: 34083676 Free PMC article.

8

Modulation of ERCC1-XPF Heterodimerization Inhibition via Structural Modification of Small Molecule Inhibitor Side-Chains.

Weilbeer C, Jay D, Donnelly JC, Gentile F, Karimi-Busheri F, Yang X, Mani RS, Yu Y, Elmenoufy AH, Barakat KH, Tuszynski JA, Weinfeld M, West FG. Weilbeer C, et al. Among authors: west fg. Front Oncol. 2022 Mar 17;12:819172. doi: 10.3389/fonc.2022.819172. eCollection 2022. Front Oncol. 2022. PMID: 35372043 Free PMC article.

9

Structures reveal details of small molecule binding to cardiac troponin.

Cai F, Li MX, Pineda-Sanabria SE, Gelozia S, Lindert S, West F, Sykes BD, Hwang PM. Cai F, et al. J Mol Cell Cardiol. 2016 Dec;101:134-144. doi: 10.1016/j.yjmcc.2016.10.016. Epub 2016 Nov 5. J Mol Cell Cardiol. 2016. PMID: 27825981 Free PMC article. Review.

10

Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway.

Elmenoufy AH, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan OM, Mani RS, Ciniero G, Tuszynski JA, Weinfeld M, West FG. Elmenoufy AH, et al. Among authors: west fg. Eur J Med Chem. 2020 Oct 15;204:112658. doi: 10.1016/j.ejmech.2020.112658. Epub 2020 Jul 22. Eur J Med Chem. 2020. PMID: 32738410

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