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Mitochondria in innate immune responses.
West AP, Shadel GS, Ghosh S. West AP, et al. Nat Rev Immunol. 2011 Jun;11(6):389-402. doi: 10.1038/nri2975. Epub 2011 May 20. Nat Rev Immunol. 2011. PMID: 21597473 Free PMC article. Review.
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Rongvaux A, et al. Among authors: west ap. Cell. 2014 Dec 18;159(7):1563-77. doi: 10.1016/j.cell.2014.11.037. Cell. 2014. PMID: 25525875 Free PMC article.
Mitochondrial DNA stress primes the antiviral innate immune response.
West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. West AP, et al. Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2. Nature. 2015. PMID: 25642965 Free PMC article.
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Zhao B, Du F, Xu P, Shu C, Sankaran B, Bell SL, Liu M, Lei Y, Gao X, Fu X, Zhu F, Liu Y, Laganowsky A, Zheng X, Ji JY, West AP, Watson RO, Li P. Zhao B, et al. Among authors: west ap. Nature. 2019 May;569(7758):718-722. doi: 10.1038/s41586-019-1228-x. Epub 2019 May 22. Nature. 2019. PMID: 31118511 Free PMC article.
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
Yambire KF, Rostosky C, Watanabe T, Pacheu-Grau D, Torres-Odio S, Sanchez-Guerrero A, Senderovich O, Meyron-Holtz EG, Milosevic I, Frahm J, West AP, Raimundo N. Yambire KF, et al. Among authors: west ap. Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031. Elife. 2019. PMID: 31793879 Free PMC article.
Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.
Key J, Maletzko A, Kohli A, Gispert S, Torres-Odio S, Wittig I, Heidler J, Bárcena C, López-Otín C, Lei Y, West AP, Münch C, Auburger G. Key J, et al. Among authors: west ap. Neurogenetics. 2020 Jul;21(3):187-203. doi: 10.1007/s10048-020-00609-2. Epub 2020 Apr 28. Neurogenetics. 2020. PMID: 32342250 Free PMC article.
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Wu Z, et al. Among authors: west ap. Nat Metab. 2019 Dec;1(12):1209-1218. doi: 10.1038/s42255-019-0150-8. Epub 2019 Dec 9. Nat Metab. 2019. PMID: 32395698 Free PMC article.
189 results