West AB - Search Results

1

Anionic nanoplastic contaminants promote Parkinson's disease-associated α-synuclein aggregation.

Liu Z, Sokratian A, Duda AM, Xu E, Stanhope C, Fu A, Strader S, Li H, Yuan Y, Bobay BG, Sipe J, Bai K, Lundgaard I, Liu N, Hernandez B, Bowes Rickman C, Miller SE, West AB. Liu Z, et al. Among authors: west ab. Sci Adv. 2023 Nov 15;9(46):eadi8716. doi: 10.1126/sciadv.adi8716. Epub 2023 Nov 17. Sci Adv. 2023. PMID: 37976362 Free PMC article.

2

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.

Liu Z, West AB. Liu Z, et al. Among authors: west ab. Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):274-280. doi: 10.1016/j.bbapap.2016.12.001. Epub 2016 Dec 8. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 27939437 Free PMC article.

3

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.

Liu Z, Xu E, Zhao HT, Cole T, West AB. Liu Z, et al. Among authors: west ab. EMBO J. 2020 Oct 15;39(20):e104862. doi: 10.15252/embj.2020104862. Epub 2020 Aug 27. EMBO J. 2020. PMID: 32853409 Free PMC article.

4

Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.

Bryant N, Malpeli N, Ziaee J, Blauwendraat C, Liu Z; AMP PD Consortium; West AB. Bryant N, et al. Among authors: west ab. Hum Mol Genet. 2021 Apr 30;30(6):454-466. doi: 10.1093/hmg/ddab058. Hum Mol Genet. 2021. PMID: 33640967 Free PMC article.

5

Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.

Sokratian A, Ziaee J, Kelly K, Chang A, Bryant N, Wang S, Xu E, Li JY, Wang SH, Ervin J, Swain SM, Liddle RA, West AB. Sokratian A, et al. Among authors: west ab. Acta Neuropathol. 2021 Apr;141(4):547-564. doi: 10.1007/s00401-021-02288-1. Epub 2021 Feb 28. Acta Neuropathol. 2021. PMID: 33641009 Free PMC article.

6

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.

Xu E, Boddu R, Abdelmotilib HA, Sokratian A, Kelly K, Liu Z, Bryant N, Chandra S, Carlisle SM, Lefkowitz EJ, Harms AS, Benveniste EN, Yacoubian TA, Volpicelli-Daley LA, Standaert DG, West AB. Xu E, et al. Among authors: west ab. Mol Neurodegener. 2022 Jan 10;17(1):7. doi: 10.1186/s13024-021-00509-5. Mol Neurodegener. 2022. PMID: 35012605 Free PMC article.

7

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration.

Hastings L, Sokratian A, Apicco DJ, Stanhope CM, Smith L, Hirst WD, West AB, Kelly K. Hastings L, et al. Among authors: west ab. Brain Commun. 2022 Feb 22;4(2):fcac042. doi: 10.1093/braincomms/fcac042. eCollection 2022. Brain Commun. 2022. PMID: 35282165 Free PMC article.

8

Identification of Novel α-Synuclein Assemblies in Lewy Body Disease.

Sokratian A, Gram H, Jensen PH, West AB. Sokratian A, et al. Among authors: west ab. Mov Disord. 2023 Jan;38(1):21-22. doi: 10.1002/mds.29272. Epub 2022 Nov 14. Mov Disord. 2023. PMID: 36374937 Free PMC article. No abstract available.

9

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease.

Strader S, West AB. Strader S, et al. Among authors: west ab. Biochem Soc Trans. 2023 Apr 26;51(2):747-758. doi: 10.1042/BST20201091. Biochem Soc Trans. 2023. PMID: 37013975 Review.

10

Gut mucosal cells transfer α-synuclein to the vagus nerve.

Chandra R, Sokratian A, Chavez KR, King S, Swain SM, Snyder JC, West AB, Liddle RA. Chandra R, et al. Among authors: west ab. bioRxiv [Preprint]. 2023 Sep 5:2023.08.14.553305. doi: 10.1101/2023.08.14.553305. bioRxiv. 2023. PMID: 37645945 Free PMC article. Updated. Preprint.

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