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Caught in the act: LRRK2 in exosomes.
Wang S, West AB. Wang S, et al. Among authors: west ab. Biochem Soc Trans. 2019 Apr 30;47(2):663-670. doi: 10.1042/BST20180467. Epub 2019 Mar 5. Biochem Soc Trans. 2019. PMID: 30837321 Free PMC article. Review.
Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.
Xu E, Boddu R, Abdelmotilib HA, Sokratian A, Kelly K, Liu Z, Bryant N, Chandra S, Carlisle SM, Lefkowitz EJ, Harms AS, Benveniste EN, Yacoubian TA, Volpicelli-Daley LA, Standaert DG, West AB. Xu E, et al. Among authors: west ab. Mol Neurodegener. 2022 Jan 10;17(1):7. doi: 10.1186/s13024-021-00509-5. Mol Neurodegener. 2022. PMID: 35012605 Free PMC article.
Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, Chang A, Bryant N, Yacoubian TA, Standaert DG, Erb M, Moore DJ, Sanders LH, Lutz MW, Velmeshev D, West AB. Yuan Y, et al. Among authors: west ab. bioRxiv [Preprint]. 2024 Apr 17:2024.04.15.589570. doi: 10.1101/2024.04.15.589570. bioRxiv. 2024. PMID: 38659797 Free PMC article. Preprint.
LRRK2 secretion in exosomes is regulated by 14-3-3.
Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Fraser KB, et al. Among authors: west ab. Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886663 Free PMC article.
264 results