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The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation.
J Med Chem. 2022 Dec 22;65(24):16268-16289. doi: 10.1021/acs.jmedchem.2c00956. Epub 2022 Dec 2.
J Med Chem. 2022.
PMID: 36459434
Free PMC article.
Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.
García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U.
García-Reyes B, et al. Among authors: wesseler f.
J Med Chem. 2018 May 10;61(9):4087-4102. doi: 10.1021/acs.jmedchem.8b00095. Epub 2018 May 1.
J Med Chem. 2018.
PMID: 29630366
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Unique photoaffinity probes to study TGFβ signaling and receptor fates.
Längle D , Wesseler F , Flötgen D , Leek H , Plowright AT , Schade D .
Längle D , et al. Among authors: wesseler f.
Chem Commun (Camb). 2019 Apr 9;55(30):4323-4326. doi: 10.1039/c9cc00929a.
Chem Commun (Camb). 2019.
PMID: 30887988
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Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators.
Wesseler F, Riege D, Puthanveedu M, Halver J, Müller E, Bertrand J, Antonchick AP, Sievers S, Waldmann H, Schade D.
Wesseler F, et al.
J Med Chem. 2022 Mar 10;65(5):3978-3990. doi: 10.1021/acs.jmedchem.1c01800. Epub 2022 Feb 2.
J Med Chem. 2022.
PMID: 35108017
Free article.
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Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype.
Wesseler F, Lohmann S, Riege D, Halver J, Roth A, Pichlo C, Weber S, Takamiya M, Müller E, Ketzel J, Flegel J, Gihring A, Rastegar S, Bertrand J, Baumann U, Knippschild U, Peifer C, Sievers S, Waldmann H, Schade D.
Wesseler F, et al.
J Med Chem. 2022 Nov 24;65(22):15263-15281. doi: 10.1021/acs.jmedchem.2c01199. Epub 2022 Nov 8.
J Med Chem. 2022.
PMID: 36346705
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Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers.
Riege D, Herschel S, Heintze L, Fenkl T, Wesseler F, Sievers S, Peifer C, Schade D.
Riege D, et al. Among authors: wesseler f.
ACS Pharmacol Transl Sci. 2023 Jul 19;6(8):1207-1220. doi: 10.1021/acsptsci.3c00103. eCollection 2023 Aug 11.
ACS Pharmacol Transl Sci. 2023.
PMID: 37588754
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Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.
Längle D, Werner TR, Wesseler F, Reckzeh E, Schaumann N, Drowley L, Polla M, Plowright AT, Hirt MN, Eschenhagen T, Schade D.
Längle D, et al. Among authors: wesseler f.
ChemMedChem. 2019 Apr 17;14(8):810-822. doi: 10.1002/cmdc.201900036. Epub 2019 Feb 28.
ChemMedChem. 2019.
PMID: 30768867
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Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives.
Längle D, Wojtowicz-Piotrowski S, Priegann T, Keller N, Wesseler F, Reckzeh ES, Steffens K, Grathwol C, Lemke J, Flasshoff M, Näther C, Jonson AC, Link A, Koch O, Di Guglielmo GM, Schade D.
Längle D, et al. Among authors: wesseler f.
ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1069-1085. doi: 10.1021/acsptsci.3c00371. eCollection 2024 Apr 12.
ACS Pharmacol Transl Sci. 2024.
PMID: 38633593
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