Werz O - Search Results

1

Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization.

Cerqua I, Musella S, Peltner LK, D'Avino D, Di Sarno V, Granato E, Vestuto V, Di Matteo R, Pace S, Ciaglia T, Bilancia R, Smaldone G, Di Matteo F, Di Micco S, Bifulco G, Pepe G, Basilicata MG, Rodriquez M, Gomez-Monterrey IM, Campiglia P, Ostacolo C, Roviezzo F, Werz O, Rossi A, Bertamino A. Cerqua I, et al. Among authors: werz o. J Med Chem. 2022 Nov 10;65(21):14456-14480. doi: 10.1021/acs.jmedchem.2c00817. Epub 2022 Nov 1. J Med Chem. 2022. PMID: 36318728 Free PMC article.

2

Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.

Landwehr J, George S, Karg EM, Poeckel D, Steinhilber D, Troschuetz R, Werz O. Landwehr J, et al. Among authors: werz o. J Med Chem. 2006 Jul 13;49(14):4327-32. doi: 10.1021/jm050801i. J Med Chem. 2006. PMID: 16821792

3

Boswellic acids: biological actions and molecular targets.

Poeckel D, Werz O. Poeckel D, et al. Among authors: werz o. Curr Med Chem. 2006;13(28):3359-69. doi: 10.2174/092986706779010333. Curr Med Chem. 2006. PMID: 17168710 Review.

4

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.

Werz O, Greiner C, Koeberle A, Hoernig C, George S, Popescu L, Syha I, Schubert-Zsilavecz M, Steinhilber D. Werz O, et al. J Med Chem. 2008 Sep 11;51(17):5449-53. doi: 10.1021/jm800588x. Epub 2008 Aug 19. J Med Chem. 2008. PMID: 18710209

5

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

6

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O. Karg EM, et al. Among authors: werz o. J Med Chem. 2009 Jun 11;52(11):3474-83. doi: 10.1021/jm900212y. J Med Chem. 2009. PMID: 19492852 Free article.

7

Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).

Liedtke AJ, Keck PR, Lehmann F, Koeberle A, Werz O, Laufer SA. Liedtke AJ, et al. Among authors: werz o. J Med Chem. 2009 Aug 13;52(15):4968-72. doi: 10.1021/jm900481c. J Med Chem. 2009. PMID: 19719242

8

Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.

Koeberle A, Werz O. Koeberle A, et al. Among authors: werz o. Curr Med Chem. 2009;16(32):4274-96. doi: 10.2174/092986709789578178. Curr Med Chem. 2009. PMID: 19754418 Review.

9

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.

Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O. Koeberle A, et al. Among authors: werz o. Bioorg Med Chem. 2009 Dec 1;17(23):7924-32. doi: 10.1016/j.bmc.2009.10.025. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884011

10

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: werz o. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399

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