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Integrated spatial multiomics reveals fibroblast fate during tissue repair.
Foster DS, Januszyk M, Yost KE, Chinta MS, Gulati GS, Nguyen AT, Burcham AR, Salhotra A, Ransom RC, Henn D, Chen K, Mascharak S, Tolentino K, Titan AL, Jones RE, da Silva O, Leavitt WT, Marshall CD, des Jardins-Park HE, Hu MS, Wan DC, Wernig G, Wagh D, Coller J, Norton JA, Gurtner GC, Newman AM, Chang HY, Longaker MT. Foster DS, et al. Among authors: wernig g. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2110025118. doi: 10.1073/pnas.2110025118. Proc Natl Acad Sci U S A. 2021. PMID: 34620713 Free PMC article.
Unifying mechanism for different fibrotic diseases.
Wernig G, Chen SY, Cui L, Van Neste C, Tsai JM, Kambham N, Vogel H, Natkunam Y, Gilliland DG, Nolan G, Weissman IL. Wernig G, et al. Proc Natl Acad Sci U S A. 2017 May 2;114(18):4757-4762. doi: 10.1073/pnas.1621375114. Epub 2017 Apr 19. Proc Natl Acad Sci U S A. 2017. PMID: 28424250 Free PMC article.
Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers.
Tsai JM, Sinha R, Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW, McKenna KM, Xing L, Sandholzer M, Sales JH, Shoham M, McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Weissman IL, Rinkevich Y. Tsai JM, et al. Among authors: wernig g. Sci Transl Med. 2018 Nov 28;10(469):eaan6735. doi: 10.1126/scitranslmed.aan6735. Sci Transl Med. 2018. PMID: 30487249
Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.
Moore AL, desJardins-Park HE, Duoto BA, Mascharak S, Murphy MP, Irizarry DM, Foster DS, Jones RE, Barnes LA, Marshall CD, Ransom RC, Wernig G, Longaker MT. Moore AL, et al. Among authors: wernig g. Ann Surg. 2020 Jul;272(1):183-193. doi: 10.1097/SLA.0000000000003172. Ann Surg. 2020. PMID: 30585822 Free PMC article.
Elucidating the fundamental fibrotic processes driving abdominal adhesion formation.
Foster DS, Marshall CD, Gulati GS, Chinta MS, Nguyen A, Salhotra A, Jones RE, Burcham A, Lerbs T, Cui L, King ME, Titan AL, Ransom RC, Manjunath A, Hu MS, Blackshear CP, Mascharak S, Moore AL, Norton JA, Kin CJ, Shelton AA, Januszyk M, Gurtner GC, Wernig G, Longaker MT. Foster DS, et al. Among authors: wernig g. Nat Commun. 2020 Aug 13;11(1):4061. doi: 10.1038/s41467-020-17883-1. Nat Commun. 2020. PMID: 32792541 Free PMC article.
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring.
Mascharak S, desJardins-Park HE, Davitt MF, Griffin M, Borrelli MR, Moore AL, Chen K, Duoto B, Chinta M, Foster DS, Shen AH, Januszyk M, Kwon SH, Wernig G, Wan DC, Lorenz HP, Gurtner GC, Longaker MT. Mascharak S, et al. Among authors: wernig g. Science. 2021 Apr 23;372(6540):eaba2374. doi: 10.1126/science.aba2374. Science. 2021. PMID: 33888614 Free PMC article.
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models.
Griffin MF, Borrelli MR, Garcia JT, Januszyk M, King M, Lerbs T, Cui L, Moore AL, Shen AH, Mascharak S, Diaz Deleon NM, Adem S, Taylor WL, desJardins-Park HE, Gastou M, Patel RA, Duoto BA, Sokol J, Wei Y, Foster D, Chen K, Wan DC, Gurtner GC, Lorenz HP, Chang HY, Wernig G, Longaker MT. Griffin MF, et al. Among authors: wernig g. Sci Transl Med. 2021 Sep;13(609):eabb3312. doi: 10.1126/scitranslmed.abb3312. Epub 2021 Sep 1. Sci Transl Med. 2021. PMID: 34516825 Free PMC article.
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G. Cui L, et al. Among authors: wernig g. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2017849118. doi: 10.1073/pnas.2017849118. Proc Natl Acad Sci U S A. 2021. PMID: 33384332 Free PMC article.
34 results