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The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.
Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D'Hooge R, Löscher W, Hamel E, Schwaninger M. Ridder DA, et al. Among authors: wenzel j. J Exp Med. 2015 Sep 21;212(10):1529-49. doi: 10.1084/jem.20150165. Epub 2015 Sep 7. J Exp Med. 2015. PMID: 26347470 Free PMC article.
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.
Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M. Körbelin J, et al. Among authors: wenzel j. EMBO Mol Med. 2016 Jun 1;8(6):609-25. doi: 10.15252/emmm.201506078. Print 2016 Jun. EMBO Mol Med. 2016. PMID: 27137490 Free PMC article.
Gene therapy decreases seizures in a model of Incontinentia pigmenti.
Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M. Dogbevia GK, et al. Among authors: wenzel j. Ann Neurol. 2017 Jul;82(1):93-104. doi: 10.1002/ana.24981. Ann Neurol. 2017. PMID: 28628231
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis.
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel J, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M. Müller-Fielitz H, et al. Among authors: wenzel j. Nat Commun. 2017 Sep 7;8(1):484. doi: 10.1038/s41467-017-00604-6. Nat Commun. 2017. PMID: 28883467 Free PMC article.
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, Huber G, Brands J, Schmidt K, Assmann JC, Stölting I, Saar K, Sedlacik J, Fiehler J, Ludewig P, Wegmann M, Feller N, Richter M, Müller-Fielitz H, Walther T, König GM, Kostenis E, Raasch W, Hübner N, Gass P, Offermanns S, de Wit C, Wagner CA, Schwaninger M. Wenzel J, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1753-1761. doi: 10.1073/pnas.1907467117. Epub 2020 Jan 2. Proc Natl Acad Sci U S A. 2020. PMID: 31896584 Free PMC article.
821 results