Wen L - Search Results

1

The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source.

Wen L, Javed TA, Dobbs AK, Brown R, Niu M, Li L, Khalid A, Barakat MT, Xiao X, Yimlamai D, Konnikova L, Yu M, Byersdorfer CA, Husain SZ. Wen L, et al. Gastroenterology. 2020 Sep;159(3):1036-1050.e8. doi: 10.1053/j.gastro.2020.05.051. Epub 2020 May 20. Gastroenterology. 2020. PMID: 32445858 Free PMC article.

2

Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.

Orabi AI, Wen L, Javed TA, Le T, Guo P, Sanker S, Ricks D, Boggs K, Eisses JF, Castro C, Xiao X, Prasadan K, Esni F, Gittes GK, Husain SZ. Orabi AI, et al. Among authors: wen l. Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):119-128. doi: 10.1016/j.jcmgh.2016.08.006. Cell Mol Gastroenterol Hepatol. 2017. PMID: 28090570 Free PMC article.

3

Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models.

Biczo G, Vegh ET, Shalbueva N, Mareninova OA, Elperin J, Lotshaw E, Gretler S, Lugea A, Malla SR, Dawson D, Ruchala P, Whitelegge J, French SW, Wen L, Husain SZ, Gorelick FS, Hegyi P, Rakonczay Z Jr, Gukovsky I, Gukovskaya AS. Biczo G, et al. Among authors: wen l. Gastroenterology. 2018 Feb;154(3):689-703. doi: 10.1053/j.gastro.2017.10.012. Epub 2017 Oct 23. Gastroenterology. 2018. PMID: 29074451 Free PMC article.

4

Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles.

Boggs K, Wang T, Orabi AI, Mukherjee A, Eisses JF, Sun T, Wen L, Javed TA, Esni F, Chen W, Husain SZ. Boggs K, et al. Among authors: wen l. Sci Rep. 2018 Jan 23;8(1):1406. doi: 10.1038/s41598-018-19392-0. Sci Rep. 2018. PMID: 29362419 Free PMC article.

5

Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice.

Wen L, Javed TA, Yimlamai D, Mukherjee A, Xiao X, Husain SZ. Wen L, et al. Gastroenterology. 2018 Oct;155(4):1250-1263.e5. doi: 10.1053/j.gastro.2018.06.036. Epub 2018 Jun 19. Gastroenterology. 2018. PMID: 29928898 Free PMC article.

6

The Orai Ca²⁺ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis.

Waldron RT, Chen Y, Pham H, Go A, Su HY, Hu C, Wen L, Husain SZ, Sugar CA, Roos J, Ramos S, Lugea A, Dunn M, Stauderman K, Pandol SJ. Waldron RT, et al. Among authors: wen l. J Physiol. 2019 Jun;597(12):3085-3105. doi: 10.1113/JP277856. Epub 2019 May 22. J Physiol. 2019. PMID: 31050811 Free PMC article.

7

Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer.

Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. Saloman JL, et al. Among authors: wen l. Pancreas. 2019 Jul;48(6):759-779. doi: 10.1097/MPA.0000000000001335. Pancreas. 2019. PMID: 31206467 Free PMC article. Review.

8

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.

Mukherjee A, Ahmed N, Rose FT, Ahmad AN, Javed TA, Wen L, Bottino R, Xiao X, Kilberg MS, Husain SZ. Mukherjee A, et al. Among authors: wen l. Cell Mol Gastroenterol Hepatol. 2020;9(1):1-13. doi: 10.1016/j.jcmgh.2019.08.003. Epub 2019 Aug 14. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31421261 Free PMC article.

9

Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.

Hernandez G, Luo T, Javed TA, Wen L, Kalwat MA, Vale K, Ammouri F, Husain SZ, Kliewer SA, Mangelsdorf DJ. Hernandez G, et al. Among authors: wen l. Sci Transl Med. 2020 Jan 8;12(525):eaay5186. doi: 10.1126/scitranslmed.aay5186. Sci Transl Med. 2020. PMID: 31915301 Free PMC article.

10

Dopamine D2 receptor activator quinpirole protects against trypsinogen activation during acute pancreatitis via upregulating HSP70.

Ye X, Han X, Li B, Dai J, Wu Z, He Y, Wen L, Hu G. Ye X, et al. Among authors: wen l. Am J Physiol Gastrointest Liver Physiol. 2020 Jun 1;318(6):G1000-G1012. doi: 10.1152/ajpgi.00354.2019. Epub 2020 Apr 20. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 32308041 Free article.

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