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Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Chen H, Lin S, Yang F, Chen Z, Guo L, Yang J, Lin X, Wang L, Duan Y, Wen A, Zhang X, Dai Y, Yin K, Yuan X, Yu C, He Y, He B, Cao Y, Dong H, Li J, Zhao Q, Liu Q, Lu G. Chen H, et al. Among authors: wen a. PLoS Pathog. 2023 Oct 13;19(10):e1011694. doi: 10.1371/journal.ppat.1011694. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37831643 Free PMC article.
Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: Unveiling their roles in the modulation of platelet activation and thrombus formation.
Zhang Y, Xin G, Zhou Q, Yu X, Feng L, Wen A, Zhang K, Wen T, Zhou X, Wu Q, He H, Huang W. Zhang Y, et al. Among authors: wen t, wen a. Toxicol Appl Pharmacol. 2024 Mar;484:116871. doi: 10.1016/j.taap.2024.116871. Epub 2024 Feb 28. Toxicol Appl Pharmacol. 2024. PMID: 38423217
Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding.
Lin S, Chen Z, Zhang X, Wen A, Yuan X, Yu C, Yang J, He B, Cao Y, Lu G. Lin S, et al. Among authors: wen a. Signal Transduct Target Ther. 2022 Feb 21;7(1):56. doi: 10.1038/s41392-022-00914-2. Signal Transduct Target Ther. 2022. PMID: 35190526 Free PMC article. No abstract available.
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.
Ye F, Lin X, Chen Z, Yang F, Lin S, Yang J, Chen H, Sun H, Wang L, Wen A, Zhang X, Dai Y, Cao Y, Yang J, Shen G, Yang L, Li J, Wang Z, Wang W, Wei X, Lu G. Ye F, et al. Among authors: wen a. Signal Transduct Target Ther. 2021 Sep 16;6(1):343. doi: 10.1038/s41392-021-00756-4. Signal Transduct Target Ther. 2021. PMID: 34531369 Free PMC article.
Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.
Yue D, Chen Z, Yang F, Ye F, Lin S, He B, Cheng Y, Wang J, Chen Z, Lin X, Yang J, Chen H, Zhang Z, You Y, Sun H, Wen A, Wang L, Zheng Y, Cao Y, Li Y, Lu G. Yue D, et al. Among authors: wen a. Sci Adv. 2020 May 13;6(20):eaba5147. doi: 10.1126/sciadv.aba5147. eCollection 2020 May. Sci Adv. 2020. PMID: 32426511 Free PMC article.
722 results