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Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A. Bultmann-Mellin I, et al. Among authors: wempe f. Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20. Dis Model Mech. 2015. PMID: 25713297 Free PMC article.
Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. Sterner-Kock A, et al. Among authors: wempe f. Genes Dev. 2002 Sep 1;16(17):2264-73. doi: 10.1101/gad.229102. Genes Dev. 2002. PMID: 12208849 Free PMC article.
Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.
Bultmann-Mellin I, Dinger K, Debuschewitz C, Loewe KMA, Melcher Y, Plum MTW, Appel S, Rappl G, Willenborg S, Schauss AC, Jüngst C, Krüger M, Dressler S, Nakamura T, Wempe F, Alejandre Alcázar MA, Sterner-Kock A. Bultmann-Mellin I, et al. Among authors: wempe f. Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L687-L698. doi: 10.1152/ajplung.00031.2017. Epub 2017 Jul 6. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28684544 Free article.
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H. Heidler J, et al. Among authors: wempe f. Dis Model Mech. 2013 Nov;6(6):1378-87. doi: 10.1242/dmm.013482. Epub 2013 Aug 29. Dis Model Mech. 2013. PMID: 24046361 Free PMC article.
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K. Petrova TV, et al. Among authors: wempe f. Cancer Cell. 2008 May;13(5):407-19. doi: 10.1016/j.ccr.2008.02.020. Cancer Cell. 2008. PMID: 18455124 Free article.
33 results