Welzel AT - Search Results

1

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: welzel at. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

2

Aberrant protein structure and diseases of the brain.

Welzel AT, Walsh DM. Welzel AT, et al. Ir J Med Sci. 2011 Mar;180(1):15-22. doi: 10.1007/s11845-010-0606-z. Epub 2010 Oct 20. Ir J Med Sci. 2011. PMID: 20960238 Review.

3

Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.

Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Klyubin I, et al. Among authors: welzel at. J Neurosci. 2008 Apr 16;28(16):4231-7. doi: 10.1523/JNEUROSCI.5161-07.2008. J Neurosci. 2008. PMID: 18417702 Free PMC article.

4

Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain.

Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Shankar GM, et al. Among authors: welzel at. Methods Mol Biol. 2011;670:33-44. doi: 10.1007/978-1-60761-744-0_3. Methods Mol Biol. 2011. PMID: 20967581

5

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Welzel AT, et al. Biochemistry. 2014 Jun 24;53(24):3908-21. doi: 10.1021/bi5003053. Biochemistry. 2014. PMID: 24840308 Free PMC article.

6

Cognitive effects of cell-derived and synthetically derived Aβ oligomers.

Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. Reed MN, et al. Among authors: welzel at. Neurobiol Aging. 2011 Oct;32(10):1784-94. doi: 10.1016/j.neurobiolaging.2009.11.007. Epub 2010 Jan 19. Neurobiol Aging. 2011. PMID: 20031278 Free PMC article.

7

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM; Medical Research Council Cognitive Function and Ageing Study. Mc Donald JM, et al. Among authors: welzel at. Brain. 2010 May;133(Pt 5):1328-41. doi: 10.1093/brain/awq065. Epub 2010 Apr 19. Brain. 2010. PMID: 20403962 Free PMC article.

8

A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.

O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM. O'Nuallain B, et al. J Neurochem. 2011 Oct;119(1):189-201. doi: 10.1111/j.1471-4159.2011.07389.x. Epub 2011 Aug 22. J Neurochem. 2011. PMID: 21781116 Free PMC article.

9

IgG Conformer's Binding to Amyloidogenic Aggregates.

Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B. Phay M, et al. Among authors: welzel at. PLoS One. 2015 Sep 14;10(9):e0137344. doi: 10.1371/journal.pone.0137344. eCollection 2015. PLoS One. 2015. PMID: 26367058 Free PMC article.

10

Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide.

Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B. Welzel AT, et al. PLoS One. 2012;7(11):e50317. doi: 10.1371/journal.pone.0050317. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209707 Free PMC article.

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