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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice.
Qiu Y, Buffonge S, Ramnath R, Jenner S, Fawaz S, Arkill KP, Neal C, Verkade P, White SJ, Hezzell M, Salmon AHJ, Suleiman MS, Welsh GI, Foster RR, Madeddu P, Satchell SC. Qiu Y, et al. Among authors: welsh gi. Diabetologia. 2022 May;65(5):879-894. doi: 10.1007/s00125-022-05650-4. Epub 2022 Feb 25. Diabetologia. 2022. PMID: 35211778 Free PMC article.
The human glomerular podocyte is a novel target for insulin action.
Coward RJ, Welsh GI, Yang J, Tasman C, Lennon R, Koziell A, Satchell S, Holman GD, Kerjaschki D, Tavaré JM, Mathieson PW, Saleem MA. Coward RJ, et al. Among authors: welsh gi. Diabetes. 2005 Nov;54(11):3095-102. doi: 10.2337/diabetes.54.11.3095. Diabetes. 2005. PMID: 16249431
Insulin signaling to the glomerular podocyte is critical for normal kidney function.
Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM. Welsh GI, et al. Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015. Cell Metab. 2010. PMID: 20889126 Free PMC article.
High glucose causes dysfunction of the human glomerular endothelial glycocalyx.
Singh A, Fridén V, Dasgupta I, Foster RR, Welsh GI, Tooke JE, Haraldsson B, Mathieson PW, Satchell SC. Singh A, et al. Among authors: welsh gi. Am J Physiol Renal Physiol. 2011 Jan;300(1):F40-8. doi: 10.1152/ajprenal.00103.2010. Epub 2010 Oct 27. Am J Physiol Renal Physiol. 2011. PMID: 20980411 Free PMC article.
135 results