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Pharmacological inhibition of FTO.
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD. McMurray F, et al. Among authors: wells s. PLoS One. 2015 Apr 1;10(4):e0121829. doi: 10.1371/journal.pone.0121829. eCollection 2015. PLoS One. 2015. PMID: 25830347 Free PMC article.
A gene-driven ENU-based approach to generating an allelic series in any gene.
Quwailid MM, Hugill A, Dear N, Vizor L, Wells S, Horner E, Fuller S, Weedon J, McMath H, Woodman P, Edwards D, Campbell D, Rodger S, Carey J, Roberts A, Glenister P, Lalanne Z, Parkinson N, Coghill EL, McKeone R, Cox S, Willan J, Greenfield A, Keays D, Brady S, Spurr N, Gray I, Hunter J, Brown SD, Cox RD. Quwailid MM, et al. Among authors: wells s. Mamm Genome. 2004 Aug;15(8):585-91. doi: 10.1007/s00335-004-2379-z. Mamm Genome. 2004. PMID: 15457338
ENU mutagenesis, a way forward to understand gene function.
Acevedo-Arozena A, Wells S, Potter P, Kelly M, Cox RD, Brown SD. Acevedo-Arozena A, et al. Among authors: wells s. Annu Rev Genomics Hum Genet. 2008;9:49-69. doi: 10.1146/annurev.genom.9.081307.164224. Annu Rev Genomics Hum Genet. 2008. PMID: 18949851 Review.
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract.
Pastorelli LM, Wells S, Fray M, Smith A, Hough T, Harfe BD, McManus MT, Smith L, Woolf AS, Cheeseman M, Greenfield A. Pastorelli LM, et al. Among authors: wells s. Mamm Genome. 2009 Mar;20(3):140-51. doi: 10.1007/s00335-008-9169-y. Epub 2009 Jan 24. Mamm Genome. 2009. PMID: 19169742
EuroPhenome: a repository for high-throughput mouse phenotyping data.
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J; EUMODIC Consortium; de Angelis MH, Brown SD, Hancock JM, Mallon AM. Morgan H, et al. Among authors: wells s. Nucleic Acids Res. 2010 Jan;38(Database issue):D577-85. doi: 10.1093/nar/gkp1007. Epub 2009 Nov 23. Nucleic Acids Res. 2010. PMID: 19933761 Free PMC article.
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Ashrafian H, Docherty L, Leo V, Towlson C, Neilan M, Steeples V, Lygate CA, Hough T, Townsend S, Williams D, Wells S, Norris D, Glyn-Jones S, Land J, Barbaric I, Lalanne Z, Denny P, Szumska D, Bhattacharya S, Griffin JL, Hargreaves I, Fernandez-Fuentes N, Cheeseman M, Watkins H, Dear TN. Ashrafian H, et al. Among authors: wells s. PLoS Genet. 2010 Jun 24;6(6):e1001000. doi: 10.1371/journal.pgen.1001000. PLoS Genet. 2010. PMID: 20585624 Free PMC article.
Overexpression of Fto leads to increased food intake and results in obesity.
Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, Wells S, Brüning JC, Nolan PM, Ashcroft FM, Cox RD. Church C, et al. Among authors: wells s. Nat Genet. 2010 Dec;42(12):1086-92. doi: 10.1038/ng.713. Epub 2010 Nov 14. Nat Genet. 2010. PMID: 21076408 Free PMC article.
1,728 results