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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity.
Frison M, Faccenda D, Abeti R, Rigon M, Strobbe D, England-Rendon BS, Cash D, Barnes K, Sadeghian M, Sajic M, Wells LA, Xia D, Giunti P, Smith K, Mortiboys H, Turkheimer FE, Campanella M. Frison M, et al. Among authors: wells la. Mol Psychiatry. 2021 Jul;26(7):2721-2739. doi: 10.1038/s41380-021-01050-z. Epub 2021 Mar 4. Mol Psychiatry. 2021. PMID: 33664474 Free PMC article.
Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer's disease patients and control subjects.
Varrone A, Oikonen V, Forsberg A, Joutsa J, Takano A, Solin O, Haaparanta-Solin M, Nag S, Nakao R, Al-Tawil N, Wells LA, Rabiner EA, Valencia R, Schultze-Mosgau M, Thiele A, Vollmer S, Dyrks T, Lehmann L, Heinrich T, Hoffmann A, Nordberg A, Halldin C, Rinne JO. Varrone A, et al. Among authors: wells la. Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):438-46. doi: 10.1007/s00259-014-2955-8. Epub 2014 Nov 21. Eur J Nucl Med Mol Imaging. 2015. PMID: 25412766 Clinical Trial.
Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.
Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LA, Taylor PC, Amor S, Antel JP, Matthews PM, Moore CS. Owen DR, et al. Among authors: wells l. J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690. doi: 10.1177/0271678X17710182. Epub 2017 May 22. J Cereb Blood Flow Metab. 2017. PMID: 28530125 Free PMC article.
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine.
Kokkinou M, Irvine EE, Bonsall DR, Natesan S, Wells LA, Smith M, Glegola J, Paul EJ, Tossell K, Veronese M, Khadayate S, Dedic N, Hopkins SC, Ungless MA, Withers DJ, Howes OD. Kokkinou M, et al. Among authors: wells la. Mol Psychiatry. 2021 Jun;26(6):2562-2576. doi: 10.1038/s41380-020-0740-6. Epub 2020 May 7. Mol Psychiatry. 2021. PMID: 32382134 Free PMC article.
Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity.
Halff EF, Natesan S, Bonsall DR, Veronese M, Garcia-Hidalgo A, Kokkinou M, Tang SP, Riggall LJ, Gunn RN, Irvine EE, Withers DJ, Wells LA, Howes OD. Halff EF, et al. Among authors: wells la. Mol Imaging. 2022 Oct 28;2022:4419221. doi: 10.1155/2022/4419221. eCollection 2022. Mol Imaging. 2022. PMID: 36721730 Free PMC article.
Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study.
Petty A, Garcia-Hidalgo A, Halff EF, Natesan S, Withers DJ, Irvine EE, Kokkinou M, Wells LA, Bonsall DR, Tang SP, Veronese M, Howes OD. Petty A, et al. Among authors: wells la. Mol Imaging Biol. 2023 Dec;25(6):1054-1062. doi: 10.1007/s11307-023-01865-y. Epub 2023 Oct 23. Mol Imaging Biol. 2023. PMID: 37872462 Free PMC article.
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