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Unraveling the mechanism of cell death induced by chemical fibrils.
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: wells ja. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.
Methods for the proteomic identification of protease substrates.
Agard NJ, Wells JA. Agard NJ, et al. Among authors: wells ja. Curr Opin Chem Biol. 2009 Dec;13(5-6):503-9. doi: 10.1016/j.cbpa.2009.07.026. Epub 2009 Sep 2. Curr Opin Chem Biol. 2009. PMID: 19729334 Free PMC article. Review.
Small-molecule activators of a proenzyme.
Wolan DW, Zorn JA, Gray DC, Wells JA. Wolan DW, et al. Among authors: wells ja. Science. 2009 Nov 6;326(5954):853-8. doi: 10.1126/science.1177585. Science. 2009. PMID: 19892984 Free PMC article.
Turning enzymes ON with small molecules.
Zorn JA, Wells JA. Zorn JA, et al. Among authors: wells ja. Nat Chem Biol. 2010 Mar;6(3):179-188. doi: 10.1038/nchembio.318. Nat Chem Biol. 2010. PMID: 20154666
Inflammatory stimuli regulate caspase substrate profiles.
Agard NJ, Maltby D, Wells JA. Agard NJ, et al. Among authors: wells ja. Mol Cell Proteomics. 2010 May;9(5):880-93. doi: 10.1074/mcp.M900528-MCP200. Epub 2010 Feb 20. Mol Cell Proteomics. 2010. PMID: 20173201 Free PMC article.
Identification of specific tethered inhibitors for caspase-5.
Gao J, Wells JA. Gao J, et al. Among authors: wells ja. Chem Biol Drug Des. 2012 Feb;79(2):209-15. doi: 10.1111/j.1747-0285.2011.01261.x. Epub 2011 Nov 28. Chem Biol Drug Des. 2012. PMID: 22014003 Free PMC article.
Global kinetic analysis of proteolysis via quantitative targeted proteomics.
Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Agard NJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1913-8. doi: 10.1073/pnas.1117158109. Epub 2012 Jan 23. Proc Natl Acad Sci U S A. 2012. PMID: 22308409 Free PMC article.
515 results