Wells G - Search Results

1

Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.

Martín-Cámara O, Arribas M, Wells G, Morales-Tenorio M, Martín-Requero Á, Porras G, Martínez A, Giorgi G, López-Alvarado P, Lastres-Becker I, Menéndez JC. Martín-Cámara O, et al. Among authors: wells g. J Med Chem. 2022 Feb 10;65(3):1867-1882. doi: 10.1021/acs.jmedchem.1c01255. Epub 2022 Jan 5. J Med Chem. 2022. PMID: 34985276 Free PMC article.

2

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.

Wells G, Suggitt M, Coffils M, Baig MA, Howard PW, Loadman PM, Hartley JA, Jenkins TC, Thurston DE. Wells G, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2147-51. doi: 10.1016/j.bmcl.2008.01.083. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18280154

3

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity.

Hancock R, Schaap M, Pfister H, Wells G. Hancock R, et al. Among authors: wells g. Org Biomol Chem. 2013 Jun 7;11(21):3553-7. doi: 10.1039/c3ob40249e. Epub 2013 Apr 24. Org Biomol Chem. 2013. PMID: 23615671

4

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction.

Bertrand HC, Schaap M, Baird L, Georgakopoulos ND, Fowkes A, Thiollier C, Kachi H, Dinkova-Kostova AT, Wells G. Bertrand HC, et al. Among authors: wells g. J Med Chem. 2015 Sep 24;58(18):7186-94. doi: 10.1021/acs.jmedchem.5b00602. J Med Chem. 2015. PMID: 26348784

5

Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction.

Wells G. Wells G. Biochem Soc Trans. 2015 Aug;43(4):674-9. doi: 10.1042/BST20150051. Epub 2015 Aug 3. Biochem Soc Trans. 2015. PMID: 26551711 Review.

6

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease.

Gameiro I, Michalska P, Tenti G, Cores Á, Buendia I, Rojo AI, Georgakopoulos ND, Hernández-Guijo JM, Teresa Ramos M, Wells G, López MG, Cuadrado A, Menéndez JC, León R. Gameiro I, et al. Among authors: wells g. Sci Rep. 2017 Mar 31;7:45701. doi: 10.1038/srep45701. Sci Rep. 2017. PMID: 28361919 Free PMC article.

7

Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids.

Georgakopoulos ND, Talapatra SK, Gatliff J, Kozielski F, Wells G. Georgakopoulos ND, et al. Among authors: wells g. Chembiochem. 2018 Sep 4;19(17):1810-1816. doi: 10.1002/cbic.201800170. Epub 2018 Jul 18. Chembiochem. 2018. PMID: 29927029 Free PMC article.

8

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode.

Georgakopoulos N, Talapatra S, Dikovskaya D, Dayalan Naidu S, Higgins M, Gatliff J, Ayhan A, Nikoloudaki R, Schaap M, Valko K, Javid F, Dinkova-Kostova AT, Kozielski F, Wells G. Georgakopoulos N, et al. Among authors: wells g. J Med Chem. 2022 May 26;65(10):7380-7398. doi: 10.1021/acs.jmedchem.2c00457. Epub 2022 May 12. J Med Chem. 2022. PMID: 35549469 Free PMC article.

9

Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance.

Zhou J, Stapleton P, Xavier-Junior FH, Schatzlein A, Haider S, Healy J, Wells G. Zhou J, et al. Among authors: wells g. Eur J Med Chem. 2022 Oct 5;240:114571. doi: 10.1016/j.ejmech.2022.114571. Epub 2022 Jun 28. Eur J Med Chem. 2022. PMID: 35792385 Free article.

10

The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance.

Srivastava R, Fernández-Ginés R, Encinar JA, Cuadrado A, Wells G. Srivastava R, et al. Among authors: wells g. Free Radic Biol Med. 2022 Nov 1;192:246-260. doi: 10.1016/j.freeradbiomed.2022.09.023. Epub 2022 Sep 28. Free Radic Biol Med. 2022. PMID: 36181972 Free article. Review.

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