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Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: wellington ma. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Butts A, et al. mBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13. mBio. 2014. PMID: 24520056 Free PMC article.
Catching fire: Candida albicans, macrophages, and pyroptosis.
Krysan DJ, Sutterwala FS, Wellington M. Krysan DJ, et al. PLoS Pathog. 2014 Jun 26;10(6):e1004139. doi: 10.1371/journal.ppat.1004139. eCollection 2014 Jun. PLoS Pathog. 2014. PMID: 24967821 Free PMC article. No abstract available.
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. Koselny K, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. doi: 10.1128/AAC.01061-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27645246 Free PMC article.
46 results