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A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.
Lo YH, Kolahi KS, Du Y, Chang CY, Krokhotin A, Nair A, Sobba WD, Karlsson K, Jones SJ, Longacre TA, Mah AT, Tercan B, Sockell A, Xu H, Seoane JA, Chen J, Shmulevich I, Weissman JS, Curtis C, Califano A, Fu H, Crabtree GR, Kuo CJ. Lo YH, et al. Among authors: weissman js. Cancer Discov. 2021 Jun;11(6):1562-1581. doi: 10.1158/2159-8290.CD-20-1109. Epub 2021 Jan 15. Cancer Discov. 2021. PMID: 33451982 Free PMC article.
Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Cho SW, et al. Among authors: weissman js. Cell. 2018 May 31;173(6):1398-1412.e22. doi: 10.1016/j.cell.2018.03.068. Epub 2018 May 3. Cell. 2018. PMID: 29731168 Free PMC article.
Pervasive functional translation of noncanonical human open reading frames.
Chen J, Brunner AD, Cogan JZ, Nuñez JK, Fields AP, Adamson B, Itzhak DN, Li JY, Mann M, Leonetti MD, Weissman JS. Chen J, et al. Among authors: weissman js. Science. 2020 Mar 6;367(6482):1140-1146. doi: 10.1126/science.aay0262. Science. 2020. PMID: 32139545 Free PMC article.
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.
Replogle JM, Norman TM, Xu A, Hussmann JA, Chen J, Cogan JZ, Meer EJ, Terry JM, Riordan DP, Srinivas N, Fiddes IT, Arthur JG, Alvarado LJ, Pfeiffer KA, Mikkelsen TS, Weissman JS, Adamson B. Replogle JM, et al. Among authors: weissman js. Nat Biotechnol. 2020 Aug;38(8):954-961. doi: 10.1038/s41587-020-0470-y. Epub 2020 Mar 30. Nat Biotechnol. 2020. PMID: 32231336 Free PMC article.
Structured elements drive extensive circular RNA translation.
Chen CK, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, Chang HY. Chen CK, et al. Among authors: weissman js. Mol Cell. 2021 Oct 21;81(20):4300-4318.e13. doi: 10.1016/j.molcel.2021.07.042. Epub 2021 Aug 25. Mol Cell. 2021. PMID: 34437836 Free PMC article.
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Gilbert LA, et al. Among authors: weissman js. Cell. 2014 Oct 23;159(3):647-61. doi: 10.1016/j.cell.2014.09.029. Epub 2014 Oct 9. Cell. 2014. PMID: 25307932 Free PMC article.
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.
Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Zalatan JG, et al. Among authors: weissman js. Cell. 2015 Jan 15;160(1-2):339-50. doi: 10.1016/j.cell.2014.11.052. Epub 2014 Dec 18. Cell. 2015. PMID: 25533786 Free PMC article.
542 results