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Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption.
Rončević T, Gerdol M, Mardirossian M, Maleš M, Cvjetan S, Benincasa M, Maravić A, Gajski G, Krce L, Aviani I, Hrabar J, Trumbić Ž, Derks M, Pallavicini A, Weingarth M, Zoranić L, Tossi A, Mladineo I. Rončević T, et al. Among authors: weingarth m. Acta Biomater. 2022 Jul 1;146:131-144. doi: 10.1016/j.actbio.2022.04.025. Epub 2022 Apr 22. Acta Biomater. 2022. PMID: 35470073
PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections.
van Eijk M, van Dijk A, van der Ent CK, Arets HGM, Breukink E, van Os N, Adrichem R, van der Water S, Lino Gómez R, Kristensen M, Hessing M, Jekhmane S, Weingarth M, Veldhuizen RAW, Veldhuizen EJA, Haagsman HP. van Eijk M, et al. Among authors: weingarth m. Biochim Biophys Acta Gen Subj. 2021 Sep;1865(9):129951. doi: 10.1016/j.bbagen.2021.129951. Epub 2021 Jun 18. Biochim Biophys Acta Gen Subj. 2021. PMID: 34147544 Free article.
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M. Shukla R, et al. Among authors: weingarth m. Nature. 2022 Aug;608(7922):390-396. doi: 10.1038/s41586-022-05019-y. Epub 2022 Aug 3. Nature. 2022. PMID: 35922513 Free PMC article.
Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.
van Beekveld RAM, Derks MGN, Kumar R, Smid L, Maass T, Medeiros-Silva J, Breukink E, Weingarth M. van Beekveld RAM, et al. Among authors: weingarth m. Chemistry. 2022 Dec 15;28(70):e202202472. doi: 10.1002/chem.202202472. Epub 2022 Oct 25. Chemistry. 2022. PMID: 36098094 Free PMC article.
An antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: weingarth m. Cell. 2023 Sep 14;186(19):4059-4073.e27. doi: 10.1016/j.cell.2023.07.038. Epub 2023 Aug 22. Cell. 2023. PMID: 37611581 Free article.
High-resolution NMR studies of antibiotics in cellular membranes.
Medeiros-Silva J, Jekhmane S, Paioni AL, Gawarecka K, Baldus M, Swiezewska E, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: weingarth m. Nat Commun. 2018 Sep 27;9(1):3963. doi: 10.1038/s41467-018-06314-x. Nat Commun. 2018. PMID: 30262913 Free PMC article.
Towards the Native Binding Modes of Antibiotics that Target Lipid II.
Medeiros-Silva J, Jekhmane S, Breukink E, Weingarth M. Medeiros-Silva J, et al. Among authors: weingarth m. Chembiochem. 2019 Jul 15;20(14):1731-1738. doi: 10.1002/cbic.201800796. Epub 2019 May 22. Chembiochem. 2019. PMID: 30725496 Free PMC article. Review.
A new antibiotic from an uncultured bacterium binds to an immutable target.
Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, de Benedetti S, Krueger AM, Vermeulen BJA, Lavore F, Honorato RV, Grein F, Bonvin A, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T, Weingarth M. Shukla R, et al. Among authors: weingarth m. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765. doi: 10.1101/2023.05.15.540765. bioRxiv. 2023. PMID: 37292624 Free PMC article. Updated. Preprint.
58 results