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Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment.
Su X, Xu Y, Fox GC, Xiang J, Kwakwa KA, Davis JL, Belle JI, Lee WC, Wong WH, Fontana F, Hernandez-Aya LF, Kobayashi T, Tomasson HM, Su J, Bakewell SJ, Stewart SA, Egbulefu C, Karmakar P, Meyer MA, Veis DJ, DeNardo DG, Lanza GM, Achilefu S, Weilbaecher KN. Su X, et al. Among authors: weilbaecher kn. J Clin Invest. 2021 Oct 15;131(20):e145296. doi: 10.1172/JCI145296. J Clin Invest. 2021. PMID: 34520398 Free PMC article.
Platelet and osteoclast beta3 integrins are critical for bone metastasis.
Bakewell SJ, Nestor P, Prasad S, Tomasson MH, Dowland N, Mehrotra M, Scarborough R, Kanter J, Abe K, Phillips D, Weilbaecher KN. Bakewell SJ, et al. Among authors: weilbaecher kn. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14205-10. doi: 10.1073/pnas.2234372100. Epub 2003 Nov 11. Proc Natl Acad Sci U S A. 2003. PMID: 14612570 Free PMC article.
Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.
Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN. Heller E, et al. Among authors: weilbaecher kn. Cancer Res. 2012 Feb 15;72(4):897-907. doi: 10.1158/0008-5472.CAN-11-2681. Epub 2011 Dec 20. Cancer Res. 2012. PMID: 22186138 Free PMC article.
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN. Su X, et al. Among authors: weilbaecher kn. J Clin Invest. 2012 Oct;122(10):3579-92. doi: 10.1172/JCI38576. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996695 Free PMC article.
Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.
Amend SR, Wilson WC, Chu L, Lu L, Liu P, Serie D, Su X, Xu Y, Wang D, Gramolini A, Wen XY, O'Neal J, Hurchla M, Vachon CM, Colditz G, Vij R, Weilbaecher KN, Tomasson MH. Amend SR, et al. Among authors: weilbaecher kn. PLoS One. 2015 May 28;10(5):e0127828. doi: 10.1371/journal.pone.0127828. eCollection 2015. PLoS One. 2015. PMID: 26020268 Free PMC article.
CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.
Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE, Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL, Dembowsky K, Weilbaecher KN. Xiang J, et al. Among authors: weilbaecher kn. Mol Cancer Ther. 2015 Nov;14(11):2473-85. doi: 10.1158/1535-7163.MCT-15-0252. Epub 2015 Aug 12. Mol Cancer Ther. 2015. PMID: 26269605 Free PMC article.
118 results