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Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
El Hamdaoui Y, Zheng F, Fritz N, Ye L, Tran MA, Schwickert K, Schirmeister T, Braeuning A, Lichtenstein D, Hellmich UA, Weikert D, Heinrich M, Treccani G, Schäfer MKE, Nowak G, Nürnberg B, Alzheimer C, Müller CP, Friedland K. El Hamdaoui Y, et al. Among authors: weikert d. Mol Psychiatry. 2022 Dec;27(12):5070-5085. doi: 10.1038/s41380-022-01804-3. Epub 2022 Oct 12. Mol Psychiatry. 2022. PMID: 36224261 Free PMC article.
Discovery of Novel Nonpeptidic PAR2 Ligands.
Klösel I, Schmidt MF, Kaindl J, Hübner H, Weikert D, Gmeiner P. Klösel I, et al. Among authors: weikert d. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. doi: 10.1021/acsmedchemlett.0c00154. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551018 Free PMC article.
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Hellmann J, et al. Among authors: weikert d. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18059-18067. doi: 10.1073/pnas.2002704117. Epub 2020 Jul 15. Proc Natl Acad Sci U S A. 2020. PMID: 32669442 Free PMC article.
Fluorescent ligands for dopamine D2/D3 receptors.
Allikalt A, Purkayastha N, Flad K, Schmidt MF, Tabor A, Gmeiner P, Hübner H, Weikert D. Allikalt A, et al. Among authors: weikert d. Sci Rep. 2020 Dec 14;10(1):21842. doi: 10.1038/s41598-020-78827-9. Sci Rep. 2020. PMID: 33318558 Free PMC article.
43 results