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Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt.
Katreddy RR, Bollu LR, Su F, Xian N, Srivastava S, Thomas R, Dai Y, Wu B, Xu Y, Rea MA, Briggs JM, Zhang Q, Lu X, Huang G, Weihua Z. Katreddy RR, et al. Among authors: weihua z. Oncogenesis. 2018 Jan 23;7(1):5. doi: 10.1038/s41389-017-0021-7. Oncogenesis. 2018. PMID: 29358623 Free PMC article.
PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
Chen CH, Wang BW, Hsiao YC, Wu CY, Cheng FJ, Hsia TC, Chen CY, Wang Y, Weihua Z, Chou RH, Tang CH, Chen YJ, Wei YL, Hsu JL, Tu CY, Hung MC, Huang WC. Chen CH, et al. Among authors: weihua z. Oncogene. 2021 Jul;40(29):4796-4808. doi: 10.1038/s41388-021-01889-0. Epub 2021 Jun 21. Oncogene. 2021. PMID: 34155348 Free PMC article.
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.
Chen J, Lee HJ, Wu X, Huo L, Kim SJ, Xu L, Wang Y, He J, Bollu LR, Gao G, Su F, Briggs J, Liu X, Melman T, Asara JM, Fidler IJ, Cantley LC, Locasale JW, Weihua Z. Chen J, et al. Among authors: weihua z. Cancer Res. 2015 Feb 1;75(3):554-65. doi: 10.1158/0008-5472.CAN-14-2268. Epub 2014 Dec 15. Cancer Res. 2015. PMID: 25511375 Free PMC article.
ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.
Zhou Y, Bollu LR, Tozzi F, Ye X, Bhattacharya R, Gao G, Dupre E, Xia L, Lu J, Fan F, Bellister S, Ellis LM, Weihua Z. Zhou Y, et al. Among authors: weihua z. Mol Cancer Ther. 2013 Dec;12(12):2782-91. doi: 10.1158/1535-7163.MCT-13-0098. Epub 2013 Oct 16. Mol Cancer Ther. 2013. PMID: 24132143 Free PMC article.
39 results