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Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM. Erfinanda L, et al. Among authors: weidenfeld s. Sci Transl Med. 2022 Dec 7;14(674):eabg8577. doi: 10.1126/scitranslmed.abg8577. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475904
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM. Michalick L, et al. Among authors: weidenfeld s. Eur Respir J. 2021 Mar 11;57(3):2002384. doi: 10.1183/13993003.02384-2020. Print 2021 Mar. Eur Respir J. 2021. PMID: 33154030 Free PMC article.
The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment.
Timm S, Lettau M, Hegermann J, Rocha ML, Weidenfeld S, Fatykhova D, Gutbier B, Nouailles G, Lopez-Rodriguez E, Hocke A, Hippenstiel S, Witzenrath M, Kuebler WM, Ochs M. Timm S, et al. Among authors: weidenfeld s. Histochem Cell Biol. 2023 Aug;160(2):83-96. doi: 10.1007/s00418-023-02211-7. Epub 2023 Jun 29. Histochem Cell Biol. 2023. PMID: 37386200 Free PMC article.
A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration.
Pasqualon T, Pruessmeyer J, Jankowski V, Babendreyer A, Groth E, Schumacher J, Koenen A, Weidenfeld S, Schwarz N, Denecke B, Jahr H, Dreymueller D, Jankowski J, Ludwig A. Pasqualon T, et al. Among authors: weidenfeld s. Oncotarget. 2015 Oct 13;6(31):31295-312. doi: 10.18632/oncotarget.5174. Oncotarget. 2015. PMID: 26378057 Free PMC article.
14 results