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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.
Sun B, Rouzbehani OMT, Kramer RJ, Ghosh R, Perelli RM, Atkins S, Fatahian AN, Davis K, Szulik MW, Goodman MA, Hathaway MA, Chi E, Word TA, Tunuguntla H, Denfield SW, Wehrens XHT, Whitehead KJ, Abdelnasser HY, Warren JS, Wu M, Franklin S, Boudina S, Landstrom AP. Sun B, et al. Among authors: wehrens xht. Circ Heart Fail. 2023 Dec;16(12):e010351. doi: 10.1161/CIRCHEARTFAILURE.122.010351. Epub 2023 Dec 19. Circ Heart Fail. 2023. PMID: 38113297
Molecular evolution of the junctophilin gene family.
Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH. Garbino A, et al. Physiol Genomics. 2009 May 13;37(3):175-86. doi: 10.1152/physiolgenomics.00017.2009. Epub 2009 Mar 24. Physiol Genomics. 2009. PMID: 19318539 Free PMC article.
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.
Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Gurha P, et al. Circulation. 2012 Jun 5;125(22):2751-61. doi: 10.1161/CIRCULATIONAHA.111.044354. Epub 2012 May 8. Circulation. 2012. PMID: 22570371 Free PMC article.
Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure.
Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Zhang C, et al. Circulation. 2014 Apr 29;129(17):1742-50. doi: 10.1161/CIRCULATIONAHA.113.008452. Epub 2014 Feb 11. Circulation. 2014. PMID: 24519927 Free PMC article.
The junctophilin family of proteins: from bench to bedside.
Landstrom AP, Beavers DL, Wehrens XH. Landstrom AP, et al. Trends Mol Med. 2014 Jun;20(6):353-62. doi: 10.1016/j.molmed.2014.02.004. Epub 2014 Mar 14. Trends Mol Med. 2014. PMID: 24636942 Free PMC article. Review.
251 results