Wegener JW - Search Results

1

A dual-targeted drug inhibits cardiac ryanodine receptor Ca²⁺ leak but activates SERCA2a Ca²⁺ uptake.

Wegener JW, Mitronova GY, ElShareif L, Quentin C, Belov V, Pochechueva T, Hasenfuss G, Ackermann L, Lehnart SE. Wegener JW, et al. Life Sci Alliance. 2023 Nov 27;7(2):e202302278. doi: 10.26508/lsa.202302278. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 38012000 Free PMC article.

2

1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities.

Mitronova GY, Quentin C, Belov VN, Wegener JW, Kiszka KA, Lehnart SE. Mitronova GY, et al. Among authors: wegener jw. J Med Chem. 2023 Dec 14;66(23):15761-15775. doi: 10.1021/acs.jmedchem.3c01235. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37991191 Free PMC article.

3

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool.

Wegener JW, Wagdi A, Wagner E, Katschinski DM, Hasenfuss G, Bruegmann T, Lehnart SE. Wegener JW, et al. Front Physiol. 2021 Dec 9;12:777770. doi: 10.3389/fphys.2021.777770. eCollection 2021. Front Physiol. 2021. PMID: 34955889 Free PMC article.

4

A junctional cAMP compartment regulates rapid Ca²⁺ signaling in atrial myocytes.

Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis DA, Sanoudou D, Sacconi L, Hasenfuß G, Voigt N, Nikolaev VO, Lehnart SE. Brandenburg S, et al. Among authors: wegener jw. J Mol Cell Cardiol. 2022 Apr;165:141-157. doi: 10.1016/j.yjmcc.2022.01.003. Epub 2022 Jan 13. J Mol Cell Cardiol. 2022. PMID: 35033544 Free article.

5

cAMP Imaging at Ryanodine Receptors Reveals β₂-Adrenoceptor Driven Arrhythmias.

Berisha F, Götz KR, Wegener JW, Brandenburg S, Subramanian H, Molina CE, Rüffer A, Petersen J, Bernhardt A, Girdauskas E, Jungen C, Pape U, Kraft AE, Warnke S, Lindner D, Westermann D, Blankenberg S, Meyer C, Hasenfuß G, Lehnart SE, Nikolaev VO. Berisha F, et al. Among authors: wegener jw. Circ Res. 2021 Jun 25;129(1):81-94. doi: 10.1161/CIRCRESAHA.120.318234. Epub 2021 Apr 27. Circ Res. 2021. PMID: 33902292

6

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes.

Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JRD, Sutanto H, Pacheu-Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuss G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener J, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE. Peper J, et al. Circ Res. 2021 Mar 19;128(6):e102-e120. doi: 10.1161/CIRCRESAHA.119.316547. Epub 2021 Jan 25. Circ Res. 2021. PMID: 33486968 Free article.

7

TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.

Vandewiele F, Pironet A, Jacobs G, Kecskés M, Wegener J, Kerselaers S, Hendrikx L, Verelst J, Philippaert K, Oosterlinck W, Segal A, Van Den Broeck E, Pinto S, Priori SG, Lehnart SE, Nilius B, Voets T, Vennekens R. Vandewiele F, et al. Eur Heart J. 2022 Oct 21;43(40):4195-4207. doi: 10.1093/eurheartj/ehac354. Eur Heart J. 2022. PMID: 35822895

8

Barnidipine block of L-type Ca(2+) channel currents in rat ventricular cardiomyocytes.

Wegener JW, Meyrer H, Rupp J, Nawrath H. Wegener JW, et al. Br J Pharmacol. 2000 Aug;130(8):2015-23. doi: 10.1038/sj.bjp.0703514. Br J Pharmacol. 2000. PMID: 10952695 Free PMC article.

9

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM.

Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW. Rapöhn M, et al. Among authors: wegener jw. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H599-H611. doi: 10.1152/ajpheart.00527.2023. Epub 2024 Jan 5. Am J Physiol Heart Circ Physiol. 2024. PMID: 38180453 Free article.

10

Murine cardiac growth, TRPC channels, and cGMP kinase I.

Domes K, Patrucco E, Loga F, Dietrich A, Birnbaumer L, Wegener JW, Hofmann F. Domes K, et al. Among authors: wegener jw. Pflugers Arch. 2015 Oct;467(10):2229-34. doi: 10.1007/s00424-014-1682-0. Epub 2014 Dec 30. Pflugers Arch. 2015. PMID: 25547873

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