Wee S - Search Results

1

Class IA phosphoinositide 3-kinase isoforms and human tumorigenesis: implications for cancer drug discovery and development.

Wee S, Lengauer C, Wiederschain D. Wee S, et al. Curr Opin Oncol. 2008 Jan;20(1):77-82. doi: 10.1097/CCO.0b013e3282f3111e. Curr Opin Oncol. 2008. PMID: 18043260 Review.

2

PTEN-deficient cancers depend on PIK3CB.

Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C. Wee S, et al. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. doi: 10.1073/pnas.0802655105. Epub 2008 Aug 28. Proc Natl Acad Sci U S A. 2008. PMID: 18755892 Free PMC article.

3

Why is cancer drug discovery so difficult?

Kamb A, Wee S, Lengauer C. Kamb A, et al. Among authors: wee s. Nat Rev Drug Discov. 2007 Feb;6(2):115-20. doi: 10.1038/nrd2155. Epub 2006 Dec 8. Nat Rev Drug Discov. 2007. PMID: 17159925 Review.

4

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers.

Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM, Sellers WR, Lengauer C, Stegmeier F. Wee S, et al. Cancer Res. 2009 May 15;69(10):4286-93. doi: 10.1158/0008-5472.CAN-08-4765. Epub 2009 Apr 28. Cancer Res. 2009. PMID: 19401449

5

Single-vector inducible lentiviral RNAi system for oncology target validation.

Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A, Chen Y, Caponigro G, Yao YM, Lengauer C, Sellers WR, Benson JD. Wiederschain D, et al. Among authors: wee s. Cell Cycle. 2009 Feb 1;8(3):498-504. doi: 10.4161/cc.8.3.7701. Epub 2009 Feb 25. Cell Cycle. 2009. PMID: 19177017

6

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Brachmann SM, Hofmann I, Schnell C, Fritsch C, Wee S, Lane H, Wang S, Garcia-Echeverria C, Maira SM. Brachmann SM, et al. Among authors: wee s. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10. Proc Natl Acad Sci U S A. 2009. PMID: 20007781 Free PMC article.

7

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.

Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA. Zhou C, et al. Among authors: wee s. Mol Cell. 2003 Apr;11(4):927-38. doi: 10.1016/s1097-2765(03)00136-9. Mol Cell. 2003. PMID: 12718879 Free article.

8

Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection.

Carrera AC, Wee SB, Roberts TM, Pardoll DM. Carrera AC, et al. Among authors: wee sb. J Immunol. 1992 Nov 15;149(10):3142-9. J Immunol. 1992. PMID: 1431093

9

Conservation of the COP9/signalosome in budding yeast.

Wee S, Hetfeld B, Dubiel W, Wolf DA. Wee S, et al. BMC Genet. 2002 Aug 20;3:15. doi: 10.1186/1471-2156-3-15. Epub 2002 Aug 20. BMC Genet. 2002. PMID: 12186635 Free PMC article.

10

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases.

Geyer R, Wee S, Anderson S, Yates J, Wolf DA. Geyer R, et al. Among authors: wee s. Mol Cell. 2003 Sep;12(3):783-90. doi: 10.1016/s1097-2765(03)00341-1. Mol Cell. 2003. PMID: 14527422 Free article.

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