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Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.
Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane IP, Hussain A, Qiu Y, Weber DJ, Njar VCO. Kwegyir-Afful AK, et al. Among authors: weber dj. Cancers (Basel). 2019 Oct 24;11(11):1637. doi: 10.3390/cancers11111637. Cancers (Basel). 2019. PMID: 31653008 Free PMC article.
Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Thomas E, Thankan RS, Purushottamachar P, Huang W, Kane MA, Zhang Y, Ambulos N, Weber DJ, Njar VCO. Thomas E, et al. Among authors: weber dj. Mol Carcinog. 2022 Jul;61(7):643-654. doi: 10.1002/mc.23406. Epub 2022 May 5. Mol Carcinog. 2022. PMID: 35512605 Free PMC article.
Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.
Coburn K, Melville Z, Aligholizadeh E, Roth BM, Varney KM, Carrier F, Pozharski E, Weber DJ. Coburn K, et al. Among authors: weber dj. Acta Crystallogr F Struct Biol Commun. 2017 Apr 1;73(Pt 4):209-214. doi: 10.1107/S2053230X17003454. Epub 2017 Mar 22. Acta Crystallogr F Struct Biol Commun. 2017. PMID: 28368279 Free PMC article.
In vivo screening of S100B inhibitors for melanoma therapy.
Zimmer DB, Lapidus RG, Weber DJ. Zimmer DB, et al. Among authors: weber dj. Methods Mol Biol. 2013;963:303-17. doi: 10.1007/978-1-62703-230-8_18. Methods Mol Biol. 2013. PMID: 23296618 Free PMC article.
914 results