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'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules.
MAbs. 2017 Jan;9(1):85-93. doi: 10.1080/19420862.2016.1249078. Epub 2016 Oct 27.
MAbs. 2017.
PMID: 27786601
Free PMC article.
Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth.
Jackson H, Granger D, Jones G, Anderson L, Friel S, Rycroft D, Fieles W, Tunstead J, Steward M, Wattam T, Walker A, Griggs J, Al-Hajj M, Shelton C.
Jackson H, et al.
Mol Cancer Res. 2016 Sep;14(9):859-68. doi: 10.1158/1541-7786.MCR-16-0088. Epub 2016 Jul 11.
Mol Cancer Res. 2016.
PMID: 27401612
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High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization.
Thomas P, Rees-Spear C, Griffith S, Muir L, Touizer E, Andrabi R, Priest R, Percival-Alwyn J, Hayward D, Buxton A, Traylen W, Chain B, Wattam T, Nandin IS, McCoy LE.
Thomas P, et al.
iScience. 2024 Mar 11;27(4):109495. doi: 10.1016/j.isci.2024.109495. eCollection 2024 Apr 19.
iScience. 2024.
PMID: 38550978
Free PMC article.
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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients.
Lekova E, Zelek WM, Gower D, Spitzfaden C, Osuch IH, John-Morris E, Stach L, Gormley D, Sanderson A, Bridges A, Wear ER, Petit-Frere S, Burden MN, Priest R, Wattam T, Kitchen SJ, Feeney M, Davis S, Morgan BP, Nichols EM.
Lekova E, et al.
Front Immunol. 2022 Sep 5;13:968206. doi: 10.3389/fimmu.2022.968206. eCollection 2022.
Front Immunol. 2022.
PMID: 36148231
Free PMC article.
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Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor.
Morel Y, Schiano de Colella JM, Harrop J, Deen KC, Holmes SD, Wattam TA, Khandekar SS, Truneh A, Sweet RW, Gastaut JA, Olive D, Costello RT.
Morel Y, et al. Among authors: wattam ta.
J Immunol. 2000 Oct 15;165(8):4397-404. doi: 10.4049/jimmunol.165.8.4397.
J Immunol. 2000.
PMID: 11035077
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Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord.
Cutler DJ, Morris R, Sheridhar V, Wattam TA, Holmes S, Patel S, Arch JR, Wilson S, Buckingham RE, Evans ML, Leslie RA, Williams G.
Cutler DJ, et al. Among authors: wattam ta.
Peptides. 1999 Dec;20(12):1455-70. doi: 10.1016/s0196-9781(99)00157-6.
Peptides. 1999.
PMID: 10698122
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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N.
Hagan JJ, et al. Among authors: wattam ta.
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6. doi: 10.1073/pnas.96.19.10911.
Proc Natl Acad Sci U S A. 1999.
PMID: 10485925
Free PMC article.
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Assay and purification of Fv fragments in fermenter cultures: design and evaluation of generic binding reagents.
Berry MJ, Wattam TA, Willets J, Lindner N, de Graaf T, Hunt T, Gani M, Davis PJ, Porter P.
Berry MJ, et al. Among authors: wattam ta.
J Immunol Methods. 1994 Jan 3;167(1-2):173-82. doi: 10.1016/0022-1759(94)90086-8.
J Immunol Methods. 1994.
PMID: 7508476
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