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Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.
Imrie H, Viswambharan H, Haywood NJ, Bridge KI, Yuldasheva NY, Galloway S, Simmons KJ, Cubbon RM, Sukumar P, Watt NT, Lichtenstein L, Wyatt JI, Kudo H, Goldin R, Rode B, Wheatcroft SB, Kearney MT. Imrie H, et al. Among authors: watt nt. Adipocyte. 2022 Dec;11(1):366-378. doi: 10.1080/21623945.2022.2089394. Adipocyte. 2022. PMID: 35734881 Free PMC article.
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.
Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM. Watt NT, et al. Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22. Diabetes. 2017. PMID: 28830894 Free article.
Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage.
Maqbool A, Watt NT, Haywood N, Viswambharan H, Skromna A, Makava N, Visnagri A, Shawer HM, Bridge K, Muminov SK, Griffin K, Beech DJ, Wheatcroft SB, Porter KE, Simmons KJ, Sukumar P, Shah AM, Cubbon RM, Kearney MT, Yuldasheva NY. Maqbool A, et al. Among authors: watt nt. Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C64-C74. doi: 10.1152/ajpcell.00389.2019. Epub 2020 May 13. Am J Physiol Cell Physiol. 2020. PMID: 32401607 Free PMC article.
Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity.
Haywood NJ, Luk C, Bridge KI, Drozd M, Makava N, Skromna A, Maccannell A, Ozber CH, Warmke N, Wilkinson CG, Watt NT, Koch-Paszkowski J, Teh I, Boyle JH, Smart S, Schneider JE, Yuldasheva NY, Roberts LD, Beech DJ, Sukumar P, Wheatcroft SB, Cubbon RM, Kearney MT. Haywood NJ, et al. Among authors: watt nt. EMBO Rep. 2021 May 5;22(5):e50767. doi: 10.15252/embr.202050767. Epub 2021 May 2. EMBO Rep. 2021. PMID: 33934497 Free PMC article.
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.
Walker AMN, Warmke N, Mercer B, Watt NT, Mughal R, Smith J, Galloway S, Haywood NJ, Soomro T, Griffin KJ, Wheatcroft SB, Yuldasheva NY, Beech DJ, Carmeliet P, Kearney MT, Cubbon RM. Walker AMN, et al. Among authors: watt nt. Endocrinology. 2021 Aug 1;162(8):bqab104. doi: 10.1210/endocr/bqab104. Endocrinology. 2021. PMID: 34037749 Free PMC article.
28 results