Watt AT - Search Results

1

Antisense oligonucleotide inhibition of Bcl-xL and Bid expression in liver regulates responses in a mouse model of Fas-induced fulminant hepatitis.

Zhang H, Taylor J, Luther D, Johnston J, Murray S, Wyatt JR, Watt AT, Koo S, York-DeFalco C, Stecker K, Dean NM. Zhang H, et al. Among authors: watt at. J Pharmacol Exp Ther. 2003 Oct;307(1):24-33. doi: 10.1124/jpet.103.050435. Epub 2003 Jul 31. J Pharmacol Exp Ther. 2003. PMID: 12893848

2

Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats.

Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K. Honore P, et al. Among authors: watt at. Pain. 2002 Sep;99(1-2):11-9. doi: 10.1016/s0304-3959(02)00032-5. Pain. 2002. PMID: 12237180

3

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.

Murray SF, Jazayeri A, Matthes MT, Yasumura D, Yang H, Peralta R, Watt A, Freier S, Hung G, Adamson PS, Guo S, Monia BP, LaVail MM, McCaleb ML. Murray SF, et al. Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6362-75. doi: 10.1167/iovs.15-16400. Invest Ophthalmol Vis Sci. 2015. PMID: 26436889 Free PMC article.

4

Variations in mRNA content have no effect on the potency of antisense oligonucleotides.

Miraglia L, Watt AT, Graham MJ, Crooke ST. Miraglia L, et al. Among authors: watt at. Antisense Nucleic Acid Drug Dev. 2000 Dec;10(6):453-61. doi: 10.1089/oli.1.2000.10.453. Antisense Nucleic Acid Drug Dev. 2000. PMID: 11198929

5

Peptide nucleic acids are potent modulators of endogenous pre-mRNA splicing of the murine interleukin-5 receptor-alpha chain.

Karras JG, Maier MA, Lu T, Watt A, Manoharan M. Karras JG, et al. Biochemistry. 2001 Jul 3;40(26):7853-9. doi: 10.1021/bi010263l. Biochemistry. 2001. PMID: 11425312

6

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.

Guo S, Casu C, Gardenghi S, Booten S, Aghajan M, Peralta R, Watt A, Freier S, Monia BP, Rivella S. Guo S, et al. J Clin Invest. 2013 Apr;123(4):1531-41. doi: 10.1172/JCI66969. Epub 2013 Mar 25. J Clin Invest. 2013. PMID: 23524968 Free PMC article.

7

Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potency.

Vickers TA, Freier SM, Bui HH, Watt A, Crooke ST. Vickers TA, et al. PLoS One. 2014 Oct 15;9(10):e110615. doi: 10.1371/journal.pone.0110615. eCollection 2014. PLoS One. 2014. PMID: 25334092 Free PMC article.

8

Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides.

Østergaard ME, Kumar P, Nichols J, Watt A, Sharma PK, Nielsen P, Seth PP. Østergaard ME, et al. Nucleic Acid Ther. 2015 Oct;25(5):266-74. doi: 10.1089/nat.2015.0547. Epub 2015 Jul 29. Nucleic Acid Ther. 2015. PMID: 26222265

9

Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus nephritis in mice.

Grossman TR, Hettrick LA, Johnson RB, Hung G, Peralta R, Watt A, Henry SP, Adamson P, Monia BP, McCaleb ML. Grossman TR, et al. Immunobiology. 2016 Jun;221(6):701-8. doi: 10.1016/j.imbio.2015.08.001. Epub 2015 Aug 10. Immunobiology. 2016. PMID: 26307001 Free article.

10

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.

Burel SA, Hart CE, Cauntay P, Hsiao J, Machemer T, Katz M, Watt A, Bui HH, Younis H, Sabripour M, Freier SM, Hung G, Dan A, Prakash TP, Seth PP, Swayze EE, Bennett CF, Crooke ST, Henry SP. Burel SA, et al. Nucleic Acids Res. 2016 Mar 18;44(5):2093-109. doi: 10.1093/nar/gkv1210. Epub 2015 Nov 8. Nucleic Acids Res. 2016. PMID: 26553810 Free PMC article.

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