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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ.
Kardeby C, Evans A, Campos J, Al-Wahaibi AM, Smith CW, Slater A, Martin EM, Severin S, Brill A, Pejler G, Sun Y, Watson SP. Kardeby C, et al. Among authors: watson sp. J Thromb Haemost. 2023 Jan;21(1):101-116. doi: 10.1016/j.jtha.2022.10.008. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36695374 Free article.
Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.
Damaskinaki FN, Jooss NJ, Martin EM, Clark JC, Thomas MR, Poulter NS, Emsley J, Kellam B, Watson SP, Slater A. Damaskinaki FN, et al. Among authors: watson sp. J Thromb Haemost. 2023 Feb;21(2):317-328. doi: 10.1016/j.jtha.2022.11.002. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36700508 Free article.
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy.
Alenazy FO, Harbi MH, Kavanagh DP, Price J, Brady P, Hargreaves O, Harrison P, Slater A, Tiwari A, Nicolson PLR, Connolly DL, Kirchhof P, Kalia N, Jandrot-Perrus M, Mangin PH, Watson SP, Thomas MR. Alenazy FO, et al. Among authors: watson sp. J Thromb Haemost. 2023 Nov;21(11):3236-3251. doi: 10.1016/j.jtha.2023.07.018. Epub 2023 Aug 3. J Thromb Haemost. 2023. PMID: 37541591 Free article.
Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand.
Martin EM, Clark JC, Montague SJ, Morán LA, Di Y, Bull LJ, Whittle L, Raka F, Buka RJ, Zafar I, Kardeby C, Slater A, Watson SP. Martin EM, et al. Among authors: watson sp. J Thromb Haemost. 2024 Jan;22(1):271-285. doi: 10.1016/j.jtha.2023.09.026. Epub 2023 Oct 9. J Thromb Haemost. 2024. PMID: 37813196 Free article.
Hydroxychloroquine inhibits hemolysis-induced arterial thrombosis ex vivo and improves lung perfusion in hemin-treated mice.
Bourne JH, Perrella G, El-Awaisi J, Terry LV, Tinkova V, Hogg RL, Gant P, Grygielska B, Kalia N, Kavanagh D, Brill A, Dimitrov JD, Watson SP, Rayes J. Bourne JH, et al. Among authors: watson sp. J Thromb Haemost. 2024 Apr 24:S1538-7836(24)00226-5. doi: 10.1016/j.jtha.2024.04.008. Online ahead of print. J Thromb Haemost. 2024. PMID: 38670315 Free article.
Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.
Akbulut AC, Arisz RA, Baaten CCFMJ, Baidildinova G, Barakzie A, Bauersachs R, Ten Berg J, van den Broek WWA, de Boer HC, Bonifay A, Bröker V, Buka RJ, Ten Cate H, Ten Cate-Hoek AJ, Cointe S, De Luca C, De Simone I, Diaz RV, Dignat-George F, Freson K, Gazzaniga G, van Gorp ECM, Habibi A, Henskens YMC, Iding AFJ, Khan A, Koenderink GH, Konkoth A, Lacroix R, Lahiri T, Lam W, Lamerton RE, Lorusso R, Luo Q, Maas C, McCarty OJT, van der Meijden PEJ, Meijers JCM, Mohapatra AK, Nevo N, Robles AP, Poncelet P, Reinhardt C, Ruf W, Saraswat R, Schönichen C, Schutgens R, Simioni P, Spada S, Spronk HMH, Tazhibayeva K, Thachil J, Diaz RV, Vallier L, Veninga A, Verhamme P, Visser C, Watson SP, Wenzel P, Willems RAL, Willers A, Zhang P, Zifkos K, van Zonneveld AJ. Akbulut AC, et al. Among authors: watson sp. Thromb Haemost. 2023 Aug;123(8):808-839. doi: 10.1055/a-2052-9175. Epub 2023 Mar 13. Thromb Haemost. 2023. PMID: 36913975 Free PMC article.
488 results