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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ.
Kardeby C, Evans A, Campos J, Al-Wahaibi AM, Smith CW, Slater A, Martin EM, Severin S, Brill A, Pejler G, Sun Y, Watson SP. Kardeby C, et al. Among authors: watson sp. J Thromb Haemost. 2023 Jan;21(1):101-116. doi: 10.1016/j.jtha.2022.10.008. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36695374 Free article.
Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.
Maqsood Z, Clark JC, Martin EM, Cheung YFH, Morán LA, Watson SET, Pike JA, Di Y, Poulter NS, Slater A, Lange BMH, Nieswandt B, Eble JA, Tomlinson MG, Owen DM, Stegner D, Bridge LJ, Wierling C, Watson SP. Maqsood Z, et al. Among authors: watson set, watson sp. PLoS Comput Biol. 2022 Nov 28;18(11):e1010708. doi: 10.1371/journal.pcbi.1010708. eCollection 2022 Nov. PLoS Comput Biol. 2022. PMID: 36441766 Free PMC article.
Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.
Damaskinaki FN, Jooss NJ, Martin EM, Clark JC, Thomas MR, Poulter NS, Emsley J, Kellam B, Watson SP, Slater A. Damaskinaki FN, et al. Among authors: watson sp. J Thromb Haemost. 2023 Feb;21(2):317-328. doi: 10.1016/j.jtha.2022.11.002. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36700508 Free article.
Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy.
Alenazy FO, Harbi MH, Kavanagh DP, Price J, Brady P, Hargreaves O, Harrison P, Slater A, Tiwari A, Nicolson PLR, Connolly DL, Kirchhof P, Kalia N, Jandrot-Perrus M, Mangin PH, Watson SP, Thomas MR. Alenazy FO, et al. Among authors: watson sp. J Thromb Haemost. 2023 Nov;21(11):3236-3251. doi: 10.1016/j.jtha.2023.07.018. Epub 2023 Aug 3. J Thromb Haemost. 2023. PMID: 37541591 Free article.
Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand.
Martin EM, Clark JC, Montague SJ, Morán LA, Di Y, Bull LJ, Whittle L, Raka F, Buka RJ, Zafar I, Kardeby C, Slater A, Watson SP. Martin EM, et al. Among authors: watson sp. J Thromb Haemost. 2024 Jan;22(1):271-285. doi: 10.1016/j.jtha.2023.09.026. Epub 2023 Oct 9. J Thromb Haemost. 2024. PMID: 37813196 Free article.
488 results