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PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. Keng VW, et al. Among authors: watson al. Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14. Cancer Res. 2012. PMID: 22700876 Free PMC article.
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.
Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA. Watson AL, et al. Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27. Cancer Discov. 2013. PMID: 23535903 Free PMC article.
Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.
Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA. Rahrmann EP, et al. Among authors: watson al. Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19. Nat Genet. 2013. PMID: 23685747 Free PMC article.
MMuFLR: missense mutation and frameshift location reporter.
Rathe SK, Johnson JE, Silverstein KA, Erdmann JJ, Watson AL, Popescu FE, Ohlfest JR, Largaespada DA. Rathe SK, et al. Among authors: watson al. Bioinformatics. 2013 Sep 15;29(18):2353-4. doi: 10.1093/bioinformatics/btt385. Epub 2013 Jul 3. Bioinformatics. 2013. PMID: 23825368 Free PMC article.
Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.
Rahrmann EP, Moriarity BS, Otto GM, Watson AL, Choi K, Collins MH, Wallace M, Webber BR, Forster CL, Rizzardi AE, Schmechel SC, Ratner N, Largaespada DA. Rahrmann EP, et al. Among authors: watson al. Am J Pathol. 2014 Jul;184(7):2082-98. doi: 10.1016/j.ajpath.2014.04.006. Epub 2014 May 13. Am J Pathol. 2014. PMID: 24832557 Free PMC article.
Engineered Swine Models of Cancer.
Watson AL, Carlson DF, Largaespada DA, Hackett PB, Fahrenkrug SC. Watson AL, et al. Front Genet. 2016 May 9;7:78. doi: 10.3389/fgene.2016.00078. eCollection 2016. Front Genet. 2016. PMID: 27242889 Free PMC article. Review.
93 results